Comparative venomics and preclinical efficacy evaluation of a monospecific Hemachatus antivenom towards sub-Saharan Africa cobra venoms.
African snakes
Antivenom
Antivenomics
Hemachatus
Naja
Neutralization
Preclinical studies
Journal
Journal of proteomics
ISSN: 1876-7737
Titre abrégé: J Proteomics
Pays: Netherlands
ID NLM: 101475056
Informations de publication
Date de publication:
30 05 2021
30 05 2021
Historique:
received:
27
01
2021
revised:
16
03
2021
accepted:
18
03
2021
pubmed:
30
3
2021
medline:
22
6
2021
entrez:
29
3
2021
Statut:
ppublish
Résumé
Cobras are the most medically important elapid snakes in Africa. The African genera Naja and Hemachatus include snakes with neurotoxic and cytotoxic venoms, with shared biochemical, toxinological and antigenic characteristics. We have studied the antigenic cross-reactivity of four sub-Saharan Africa cobra venoms against an experimental monospecific Hemachatus haemachatus antivenom through comparative proteomics, preclinical assessment of neutralization, and third generation antivenomics. The venoms of H. haemachatus, N. annulifera, N. mossambica and N. nigricollis share an overall qualitative family toxin composition but depart in their proportions of three-finger toxin (3FTxs) classes, phospholipases A
Identifiants
pubmed: 33775842
pii: S1874-3919(21)00095-6
doi: 10.1016/j.jprot.2021.104196
pii:
doi:
Substances chimiques
Antivenins
0
Elapid Venoms
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
104196Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.