Association of salivary steroid hormones and their ratios with time-domain heart rate variability indices in healthy individuals.

autonomic nervous system heart rate variability hypothalamic-pituitary-adrenal axis steroid hormones stress biomarkers

Journal

Journal of medical biochemistry
ISSN: 1452-8258
Titre abrégé: J Med Biochem
Pays: Serbia
ID NLM: 101315490

Informations de publication

Date de publication:
12 Mar 2021
Historique:
received: 08 04 2020
accepted: 22 06 2020
entrez: 29 3 2021
pubmed: 30 3 2021
medline: 30 3 2021
Statut: ppublish

Résumé

Stress system consists of the hypothalamicpituitary-adrenal (HPA) axis and the locus caeruleus/norepinephrine-autonomic nervous system (ANS). Traditionally, HPA axis activity is evaluated by measuring its end-product cortisol, while the activity of ANS is assessed using heart rate variability (HRV) indices. Alterations in cortisol levels and HRV measures during laboratory-based stress tasks were extensively studied in previous research. However, scarce data exist on the associations of HRV measures with the levels of other adrenal steroid hormones under baseline conditions. Thus, we aimed to evaluate the activity of the HPA axis by measuring salivary cortisol, cortisone, dehydroepiandrosterone (DHEA) levels, and their ratios and to examine its association with HRV measures in a sample of healthy young and middle-aged adults. For each participant (n=40), three data collection sessions taking place at the same time of the day were scheduled within five working days. Participants completed a self-reported questionnaire on sociodemographic and lifestyle characteristics, filled out t h e Perceived Stress Scale and State-Trait Anxiety Inventory. Also, saliva samples were collected, and physiological measures, including resting HR and HRV, were recorded during three data collection sessions. Statistically significant associations between diminished parasympathetic vagal tone evaluated by time domain HRV measures and higher salivary cortisol, lower DHEA levels, as well as decreased DHEA to cortisol ratio, were found. Also, physiological stress indicators (i.e., HRV) showed greater intraindividual stability compared with biochemical biomarkers (i.e., salivary steroid hormones) within five days. Our findings suggest that both cortisol and DHEA mediate the link between two stress-sensitive homeostatic systems. Sistem stresa se sastoji od hipotalamusno-hipofiznoadrenalne (HPA) ose i plavog jedra/norepinefrina - autonomnog nervnog sistema (ANS). Tradicionalno, aktivnost HPA ose se procenjuje merenjem kortizola u krajnjem produktu, dok se aktivnost ANS procenjuje pomoću indeksa promenljivosti otkucaja srca (HRV). Promene nivoa kortizola i HRV merene tokom stresnih zadataka u laboratorijskim uslovima su detaljno proučavane u prethodnim istraživanjima. Međutim, postoje nedovoljni podaci o povezanosti merenja HRV-a sa nivoima ostalih nadbubrežnih steroidnih hormona u osnovnom stanju. Stoga smo želeli da procenimo aktivnost HPA ose merenjem nivoa kortizola iz pljuvačke, kortizona i dehidroepiandrosterona (DHEA) i da ispitamo njihovu povezanost sa HRV merenjima na uzorku zdravih mladih ljudi i ljudi srednjih godina. Za svakog učesnika (n=40) su zakazane tri sesije prikupljanja podataka u isto doba dana tokom pet dana. Učesnici su samostalno popunili upitnik o sociodemografskim i životnim karakteristikama, ispunili su Percipiranu skalu stresa i Upitnik o anksioznosti kao stanja i osobine ličnosti. Takođe, prikupljeni su uzorci pljuvačke i urađena su fiziološka merenja, uključujući HR i HRV u mirovanju tokom tri sesije prikupljanja podataka. Otkrivene su statistički značajne veze između smanjenog parasimpatičkog vagalnog tona procenjenog vremenskim domenom HRV i višeg nivoa kortizola u pljuvački, nižeg nivoa DHEA, kao i smanjenog racija DHEA i kortizola. Takođe, pokazatelji fiziološkog stresa (tj. HRV) pokazali su veću intraindividualnu stabilnost u poređenju sa biohemijskim biomarkerima (tj. steroidnim hormonima pljuvačke) u periodu od pet dana. Naša otkrića sugerišu da kortizol i DHEA posreduju u vezi između dva homeostatska sistema osetljiva na stres.

Sections du résumé

BACKGROUND BACKGROUND
Stress system consists of the hypothalamicpituitary-adrenal (HPA) axis and the locus caeruleus/norepinephrine-autonomic nervous system (ANS). Traditionally, HPA axis activity is evaluated by measuring its end-product cortisol, while the activity of ANS is assessed using heart rate variability (HRV) indices. Alterations in cortisol levels and HRV measures during laboratory-based stress tasks were extensively studied in previous research. However, scarce data exist on the associations of HRV measures with the levels of other adrenal steroid hormones under baseline conditions. Thus, we aimed to evaluate the activity of the HPA axis by measuring salivary cortisol, cortisone, dehydroepiandrosterone (DHEA) levels, and their ratios and to examine its association with HRV measures in a sample of healthy young and middle-aged adults.
METHODS METHODS
For each participant (n=40), three data collection sessions taking place at the same time of the day were scheduled within five working days. Participants completed a self-reported questionnaire on sociodemographic and lifestyle characteristics, filled out t h e Perceived Stress Scale and State-Trait Anxiety Inventory. Also, saliva samples were collected, and physiological measures, including resting HR and HRV, were recorded during three data collection sessions.
RESULTS RESULTS
Statistically significant associations between diminished parasympathetic vagal tone evaluated by time domain HRV measures and higher salivary cortisol, lower DHEA levels, as well as decreased DHEA to cortisol ratio, were found. Also, physiological stress indicators (i.e., HRV) showed greater intraindividual stability compared with biochemical biomarkers (i.e., salivary steroid hormones) within five days.
CONCLUSIONS CONCLUSIONS
Our findings suggest that both cortisol and DHEA mediate the link between two stress-sensitive homeostatic systems.
UVOD UNASSIGNED
Sistem stresa se sastoji od hipotalamusno-hipofiznoadrenalne (HPA) ose i plavog jedra/norepinefrina - autonomnog nervnog sistema (ANS). Tradicionalno, aktivnost HPA ose se procenjuje merenjem kortizola u krajnjem produktu, dok se aktivnost ANS procenjuje pomoću indeksa promenljivosti otkucaja srca (HRV). Promene nivoa kortizola i HRV merene tokom stresnih zadataka u laboratorijskim uslovima su detaljno proučavane u prethodnim istraživanjima. Međutim, postoje nedovoljni podaci o povezanosti merenja HRV-a sa nivoima ostalih nadbubrežnih steroidnih hormona u osnovnom stanju. Stoga smo želeli da procenimo aktivnost HPA ose merenjem nivoa kortizola iz pljuvačke, kortizona i dehidroepiandrosterona (DHEA) i da ispitamo njihovu povezanost sa HRV merenjima na uzorku zdravih mladih ljudi i ljudi srednjih godina.
METODE METHODS
Za svakog učesnika (n=40) su zakazane tri sesije prikupljanja podataka u isto doba dana tokom pet dana. Učesnici su samostalno popunili upitnik o sociodemografskim i životnim karakteristikama, ispunili su Percipiranu skalu stresa i Upitnik o anksioznosti kao stanja i osobine ličnosti. Takođe, prikupljeni su uzorci pljuvačke i urađena su fiziološka merenja, uključujući HR i HRV u mirovanju tokom tri sesije prikupljanja podataka.
REZULTATI UNASSIGNED
Otkrivene su statistički značajne veze između smanjenog parasimpatičkog vagalnog tona procenjenog vremenskim domenom HRV i višeg nivoa kortizola u pljuvački, nižeg nivoa DHEA, kao i smanjenog racija DHEA i kortizola. Takođe, pokazatelji fiziološkog stresa (tj. HRV) pokazali su veću intraindividualnu stabilnost u poređenju sa biohemijskim biomarkerima (tj. steroidnim hormonima pljuvačke) u periodu od pet dana.
ZAKLJUČAK UNASSIGNED
Naša otkrića sugerišu da kortizol i DHEA posreduju u vezi između dva homeostatska sistema osetljiva na stres.

Autres résumés

Type: Publisher (srp)
Sistem stresa se sastoji od hipotalamusno-hipofiznoadrenalne (HPA) ose i plavog jedra/norepinefrina - autonomnog nervnog sistema (ANS). Tradicionalno, aktivnost HPA ose se procenjuje merenjem kortizola u krajnjem produktu, dok se aktivnost ANS procenjuje pomoću indeksa promenljivosti otkucaja srca (HRV). Promene nivoa kortizola i HRV merene tokom stresnih zadataka u laboratorijskim uslovima su detaljno proučavane u prethodnim istraživanjima. Međutim, postoje nedovoljni podaci o povezanosti merenja HRV-a sa nivoima ostalih nadbubrežnih steroidnih hormona u osnovnom stanju. Stoga smo želeli da procenimo aktivnost HPA ose merenjem nivoa kortizola iz pljuvačke, kortizona i dehidroepiandrosterona (DHEA) i da ispitamo njihovu povezanost sa HRV merenjima na uzorku zdravih mladih ljudi i ljudi srednjih godina.

Identifiants

DOI: 10.5937/jomb0-26045 PMID: 33776567 PMC: PMC7982294
pubmed: 33776567
doi: 10.5937/jomb0-26045
pii: jomb-40-2-2102173M
pmc: PMC7982294
doi:

Types de publication

Journal Article

Langues

eng

Pagination

173-180

Informations de copyright

2021 Eglė Mazgelytė, Gintaras Chomentauskas, Edita Dereškevičiūtė, Virginija Rekienė, Audronė Jakaitienė, Tomas Petrėnas, Jurgita Songailienė, Algirdas Utkus, Kučinskienė Zita Aušrelė, Dovilė Karčiauskaitė, published by CEON/CEES.

Déclaration de conflit d'intérêts

Conflict of Interest: The authors stated that they have no conflicts of interest regarding the publication of this article.

Références

Horm Behav. 2017 Mar;89:69-85
pubmed: 27979632
Aging Male. 2013 Jun;16(2):58-66
pubmed: 23581721
Psychophysiology. 2011 Mar;48(3):420-9
pubmed: 20667035
Turk Kardiyol Dern Ars. 2010 Oct;38(7):459-65
pubmed: 21206198
Sci Rep. 2019 Dec 17;9(1):19313
pubmed: 31848390
J Affect Disord. 2020 Feb 15;263:754-761
pubmed: 31630828
Psychophysiology. 1997 Nov;34(6):623-48
pubmed: 9401419
PLoS One. 2014 Sep 10;9(9):e105328
pubmed: 25207649
Ann Noninvasive Electrocardiol. 2004 Apr;9(2):156-61
pubmed: 15084213
Biol Psychol. 2012 May;90(2):143-9
pubmed: 22445967
Psychoneuroendocrinology. 2019 Apr;102:196-203
pubmed: 30579237
Front Psychol. 2017 Apr 07;8:456
pubmed: 28439244
Biol Psychol. 2013 Oct;94(2):433-40
pubmed: 24007813
Arch Endocrinol Metab. 2019 Feb;63(1):62-69
pubmed: 30864633
Front Psychol. 2017 Feb 20;8:213
pubmed: 28265249
Dev Psychobiol. 2008 Mar;50(2):171-82
pubmed: 18286584
J Psychiatr Res. 2015 Jul-Aug;66-67:24-37
pubmed: 25959615
Ann N Y Acad Sci. 2006 Nov;1088:361-72
pubmed: 17192580
J Psychosom Res. 2013 Oct;75(4):314-20
pubmed: 24119936
Ann Clin Biochem. 2009 May;46(Pt 3):183-96
pubmed: 19176642
Psychoneuroendocrinology. 2018 Aug;94:63-71
pubmed: 29758470
Hypertension. 2001 Dec 1;38(6):1330-6
pubmed: 11751713
J Physiol. 2018 Oct;596(20):4847-4861
pubmed: 30129666

Auteurs

Eglė Mazgelytė (E)

Vilnius University, Faculty of Medicine, Institute of Biomedical Sciences, Department of Physiology, Biochemistry, Microbiology, and Laboratory Medicine, Vilnius, Lithuania.

Gintaras Chomentauskas (G)

Human Study Center, Vilnius, Lithuania.

Edita Dereškevičiūtė (E)

Human Study Center, Vilnius, Lithuania.

Virginija Rekienė (V)

Human Study Center, Vilnius, Lithuania.

Audronė Jakaitienė (A)

Vilnius University, Faculty of Medicine, Institute of Biomedical Sciences, Department of Human and Medical Genetics, Vilnius, Lithuania.

Tomas Petrėnas (T)

Vilnius University, Faculty of Medicine, Institute of Biomedical Sciences, Department of Human and Medical Genetics, Vilnius, Lithuania.

Jurgita Songailienė (J)

Vilnius University, Faculty of Medicine, Institute of Biomedical Sciences, Department of Human and Medical Genetics, Vilnius, Lithuania.

Algirdas Utkus (A)

Vilnius University, Faculty of Medicine, Institute of Biomedical Sciences, Department of Human and Medical Genetics, Vilnius, Lithuania.

Kučinskienė Zita Aušrelė (KZ)

Vilnius University, Faculty of Medicine, Institute of Biomedical Sciences, Department of Physiology, Biochemistry, Microbiology, and Laboratory Medicine, Vilnius, Lithuania.

Dovilė Karčiauskaitė (D)

Vilnius University, Faculty of Medicine, Institute of Biomedical Sciences, Department of Physiology, Biochemistry, Microbiology, and Laboratory Medicine, Vilnius, Lithuania.

Classifications MeSH