Reduction of Pressure Pain Sensitivity as Novel Non-pharmacological Therapeutic Approach to Type 2 Diabetes: A Randomized Trial.
HbA1c
autonomic dysfunction
glucose control
glucose homeostasis
lateral hypothalamus
non-pharmacological intervention
pressure pain sensitivity
type 2 diabetes
Journal
Frontiers in neuroscience
ISSN: 1662-4548
Titre abrégé: Front Neurosci
Pays: Switzerland
ID NLM: 101478481
Informations de publication
Date de publication:
2021
2021
Historique:
received:
04
10
2020
accepted:
02
02
2021
entrez:
29
3
2021
pubmed:
30
3
2021
medline:
30
3
2021
Statut:
epublish
Résumé
Autonomic nervous system dysfunction (ANSD) is known to affect glucose metabolism in the mammalian body. Tradition holds that glucose homeostasis is regulated by the peripheral nervous system, and contemporary therapeutic intervention reflects this convention. The present study tested the role of cerebral regulation of ANSD as consequence of novel understanding of glucose metabolism and treatment target in type 2 diabetes (T2D), suggested by the claim that the pressure pain sensitivity (PPS) of the chest bone periosteum may be a measure of cerebral ANSD. In a randomized controlled trial of 144 patients with T2D, we tested the claim that 6 months of this treatment would reduce PPS and improve peripheral glucose metabolism. In the active treatment group, mean glycated hemoglobin A1c (HbA1c) declined from 53.8 to 50.5 mmol/mol (intragroup We conclude that the proposed approach to treatment of T2D is a potential supplement to conventional therapy. www.clinicaltrials.gov (NCT03576430).
Sections du résumé
BACKGROUND
BACKGROUND
Autonomic nervous system dysfunction (ANSD) is known to affect glucose metabolism in the mammalian body. Tradition holds that glucose homeostasis is regulated by the peripheral nervous system, and contemporary therapeutic intervention reflects this convention.
OBJECTIVES
OBJECTIVE
The present study tested the role of cerebral regulation of ANSD as consequence of novel understanding of glucose metabolism and treatment target in type 2 diabetes (T2D), suggested by the claim that the pressure pain sensitivity (PPS) of the chest bone periosteum may be a measure of cerebral ANSD.
DESIGN
METHODS
In a randomized controlled trial of 144 patients with T2D, we tested the claim that 6 months of this treatment would reduce PPS and improve peripheral glucose metabolism.
RESULTS
RESULTS
In the active treatment group, mean glycated hemoglobin A1c (HbA1c) declined from 53.8 to 50.5 mmol/mol (intragroup
CONCLUSION
CONCLUSIONS
We conclude that the proposed approach to treatment of T2D is a potential supplement to conventional therapy.
CLINICAL TRIAL REGISTRATION
BACKGROUND
www.clinicaltrials.gov (NCT03576430).
Identifiants
pubmed: 33776633
doi: 10.3389/fnins.2021.613858
pmc: PMC7991917
doi:
Banques de données
ClinicalTrials.gov
['NCT03576430']
Types de publication
Journal Article
Langues
eng
Pagination
613858Informations de copyright
Copyright © 2021 Faber, Eldrup, Selmer, Pichat, Hecquet, Watt, Kreiner, Karpatschof, Gyntelberg, Ballegaard and Gjedde.
Déclaration de conflit d'intérêts
SB is a shareholder in the company UllCare A/S that holds the patent for the PPS-measurement device. He did not participate in patient selection, examinations, or evaluation of the examinations. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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