MiR-452 Regulates C2C12 Myoblast Proliferation and Differentiation
ANGPT1
C2C12 myoblasts
differentiation
miR-452
proliferation
Journal
Frontiers in genetics
ISSN: 1664-8021
Titre abrégé: Front Genet
Pays: Switzerland
ID NLM: 101560621
Informations de publication
Date de publication:
2021
2021
Historique:
received:
15
12
2020
accepted:
02
02
2021
entrez:
29
3
2021
pubmed:
30
3
2021
medline:
30
3
2021
Statut:
epublish
Résumé
microRNAs are a kind of endogenous, non-coding, single-strand small RNA. They have been reported as an important regulatory factor in skeletal myogenesis. In this study, miR-452 was selected from RNA high-throughput sequencing data to explore its regulatory role in myogenesis. Functionally, miR-452 overexpression could promote C2C12 myoblast proliferation while inhibiting myogenic differentiation. On the contrary, inhibition of miR-452 could suppress C2C12 myoblast proliferation but accelerate myogenic differentiation. Bioinformatics analysis and dual luciferase report assays showed that
Identifiants
pubmed: 33777108
doi: 10.3389/fgene.2021.640807
pmc: PMC7994525
doi:
Types de publication
Journal Article
Langues
eng
Pagination
640807Informations de copyright
Copyright © 2021 Yang, Qi, Wang, Song, Wang, Chen, Chen, Zhang, Hu and Fang.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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