Myocarditis and Drug Rash With Eosinophilia and Systemic Symptoms Syndrome: A Deadly Combination.
amoxicillin
dress syndrome
echocardiography
lymphadenopathy
myocarditis
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
22 Feb 2021
22 Feb 2021
Historique:
entrez:
29
3
2021
pubmed:
30
3
2021
medline:
30
3
2021
Statut:
epublish
Résumé
DRESS syndrome (Drug Rash with Eosinophilia and Systemic Symptoms) is a severe delayed type IV hypersensitivity drug reaction by T helper cell 2 (Th2) and Interleukin 5 (IL-5) resulting in activation of eosinophils. It is mostly reported with antiepileptic drugs (AEDs), antibiotics, and allopurinol. Here, we present the second case of myocarditis secondary to DRESS syndrome caused by amoxicillin. Most of the case reports present with cross-reactivity among the anticonvulsants and beta-lactams, which is also rarely been reported. Amoxicillin could reactivate human herpesvirus 6 (HHV 6) and Epstein-Barr virus (EBV) with a presentation similar to DRESS syndrome, but our patient was neither taking the anticonvulsants nor have any viral infection in the recent past. His RegiSCAR score was 6, consistent with definite DRESS syndrome. Management includes identification and prompt withdrawal of the offending drug and supportive care for patients without severe organ involvement and systemic corticosteroids for patients with severe organ involvement.
Identifiants
pubmed: 33777581
doi: 10.7759/cureus.13496
pmc: PMC7990470
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e13496Informations de copyright
Copyright © 2021, De La Cruz et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Eur Heart J Case Rep. 2018 Oct 10;2(4):yty100
pubmed: 31020177
Asian Pac J Allergy Immunol. 2017 Mar;35(1):3-10
pubmed: 27996289
Proc Natl Acad Sci U S A. 2005 Mar 15;102(11):4134-9
pubmed: 15743917
Nephrol Dial Transplant. 2006 Nov;21(11):3301-3
pubmed: 16954168
Br J Clin Pharmacol. 2016 Apr;81(4):784-5
pubmed: 26594014
Br J Dermatol. 1998 Dec;139(6):1026-32
pubmed: 9990366
Joint Bone Spine. 2010 Jan;77(1):87-8
pubmed: 19854669
World Allergy Organ J. 2010 Jul;3(7):220-2
pubmed: 23282653
Joint Bone Spine. 2005 Jan;72(1):82-5
pubmed: 15681256
Pan Afr Med J. 2017 Nov 09;28:218
pubmed: 29629004
J Clin Aesthet Dermatol. 2013 Jun;6(6):31-7
pubmed: 23882307
J Family Med Prim Care. 2017 Jul-Sep;6(3):693-694
pubmed: 29417040
Br J Dermatol. 2013 Nov;169(5):1071-80
pubmed: 23855313
J Allergy Clin Immunol Pract. 2018 Sep - Oct;6(5):1766-1768
pubmed: 29408014
Am J Med. 2011 Jul;124(7):588-97
pubmed: 21592453
Eur J Dermatol. 2010 Jan-Feb;20(1):68-73
pubmed: 19822481
Ital J Pediatr. 2018 Aug 15;44(1):93
pubmed: 30111350
JAAD Case Rep. 2019 Nov 13;5(12):1018-1026
pubmed: 31763425
Toxicology. 2005 Apr 15;209(2):165-7
pubmed: 15767030
Nature. 2004 Apr 1;428(6982):486
pubmed: 15057820