Junctional Adhesion Molecule-Like Protein Promotes Tumor Progression and Metastasis

gastric cancer junctional adhesion molecule-like protein (JAML) migration p38 tumor progression

Journal

Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867

Informations de publication

Date de publication:
2021
Historique:
received: 25 05 2020
accepted: 01 02 2021
entrez: 29 3 2021
pubmed: 30 3 2021
medline: 30 3 2021
Statut: epublish

Résumé

Junctional adhesion molecule-like protein (JAML), a newly discovered junctional adhesion molecule (JAM), mediates the adhesion and migration processes of various immune cells and endothelial/epithelial cells, ultimately regulating inflammation reaction. However, its role in tumors remains to be determined. The expression of JAML was examined in gastric cancer (GC) and peritumoral tissues from 63 patients. The relationship between JAML expression and clinical characteristics was also observed.

Identifiants

DOI: 10.3389/fonc.2021.565676 PMID: 33777731 PMC: PMC7991718
pubmed: 33777731
doi: 10.3389/fonc.2021.565676
pmc: PMC7991718
doi:

Types de publication

Journal Article

Langues

eng

Pagination

565676

Informations de copyright

Copyright © 2021 Fang, Yang, Zu, Cong, Liu, Xue, Ma, Liu, Sun and Sun.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Yuying Fang (Y)

Department of Oncology, Jinan Central Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Department of Oncology, Central Hospital Affiliated to Shandong First Medical University, Jinan, China.

Jianmin Yang (J)

The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese Ministry of Health and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.

Guohong Zu (G)

Department of Oncology, Jinan Central Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Department of Oncology, Central Hospital Affiliated to Shandong First Medical University, Jinan, China.

Changsheng Cong (C)

Department of Oncology, Jinan Central Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Department of Oncology, Central Hospital Affiliated to Shandong First Medical University, Jinan, China.

Shuai Liu (S)

Department of Oncology, Jinan Central Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Department of Oncology, Central Hospital Affiliated to Shandong First Medical University, Jinan, China.

Fei Xue (F)

The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese Ministry of Health and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.

Shuzhen Ma (S)

Department of Oncology, Jinan Central Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Department of Oncology, Central Hospital Affiliated to Shandong First Medical University, Jinan, China.

Jie Liu (J)

Department of Oncology, Jinan Central Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Department of Oncology, Central Hospital Affiliated to Shandong First Medical University, Jinan, China.

Yuping Sun (Y)

Department of Oncology, Jinan Central Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Department of Oncology, Central Hospital Affiliated to Shandong First Medical University, Jinan, China.

Meili Sun (M)

Department of Oncology, Jinan Central Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Department of Oncology, Central Hospital Affiliated to Shandong First Medical University, Jinan, China.
Cardiovascular Disease Research Center of Shandong First Medical University, Central Hospital Affiliated to Shandong First Medical University, Jinan, China.

Classifications MeSH