Therapeutic Plasma Exchange in Refractory Hyperthyroidism.
Hyperthyroidism
Iodine-induced thyrotoxicosis
Therapeutic plasma exchange
Thyroid surgery
Thyrotoxicosis
Journal
European thyroid journal
ISSN: 2235-0640
Titre abrégé: Eur Thyroid J
Pays: England
ID NLM: 101604579
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
received:
31
12
2019
accepted:
05
03
2020
entrez:
29
3
2021
pubmed:
30
3
2021
medline:
30
3
2021
Statut:
ppublish
Résumé
Hyperthyroid patients who are unresponsive to medical treatment remain a challenging clinical problem. The goal of our study was to evaluate the use of therapeutic plasma exchange (TPE) in hyperthyroid patients and their outcome after TPE. We retrospectively reviewed 22 patients who underwent TPE for refractory thyrotoxicosis in our institution: 13 with Graves' disease, 7 with amiodarone-induced thyrotoxicosis (AIT), 1 with toxic goiter, and 1 pregnant patient with familial nonautoimmune thyrotoxicosis. Before TPE, all patients had severe hyperthyroidism, and antithyroid drugs were either contraindicated or not sufficiently effective to restore euthyroidism promptly. After all the TPEs, free T TPE allowed a safe decrease of 50% in thyroid hormone levels, and it should be considered for refractory hyperthyroid patients when medical treatments are contraindicated or have failed to restore euthyroidism, irrespective of the etiology of the thyrotoxicosis.
Identifiants
pubmed: 33777824
doi: 10.1159/000507019
pii: etj-0010-0086
pmc: PMC7983568
doi:
Types de publication
Journal Article
Langues
eng
Pagination
86-92Informations de copyright
Copyright © 2020 by European Thyroid Association Published by S. Karger AG, Basel.
Déclaration de conflit d'intérêts
The authors have no conflicts of interest to declare.
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