Telomere Length in Valve Tissue Is Shorter in Individuals With Aortic Stenosis and in Calcified Valve Areas.
aging
aortic stenosis
aortic valve
calcification
telomere length
Journal
Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250
Informations de publication
Date de publication:
2021
2021
Historique:
received:
16
10
2020
accepted:
15
02
2021
entrez:
29
3
2021
pubmed:
30
3
2021
medline:
30
3
2021
Statut:
epublish
Résumé
Short telomere length (TL) is associated with age-related diseases, in particular cardiovascular diseases. However, whether the onset and course of aortic stenosis (AS) is linked to TL in aortic valves remains unknown. To assess telomere dynamics (TL and telomerase activity) in aortic valves and the possible implication of TL in onset and course of AS. DNA was extracted from aortic valves obtained from 55 patients (78.2% men; age, 37-79 years), who had undergone replacement surgery due to AS (AS group, TL was shorter in calcified aortic valve areas in comparison to non-calcified areas ( Short telomeres in aortic valves may participate in the development of AS, while concurrently the calcification process seems to promote further local decrease of TL in calcified areas of valves.
Sections du résumé
BACKGROUND
BACKGROUND
Short telomere length (TL) is associated with age-related diseases, in particular cardiovascular diseases. However, whether the onset and course of aortic stenosis (AS) is linked to TL in aortic valves remains unknown.
OBJECTIVES
OBJECTIVE
To assess telomere dynamics (TL and telomerase activity) in aortic valves and the possible implication of TL in onset and course of AS.
METHODS
METHODS
DNA was extracted from aortic valves obtained from 55 patients (78.2% men; age, 37-79 years), who had undergone replacement surgery due to AS (AS group,
RESULTS
RESULTS
TL was shorter in calcified aortic valve areas in comparison to non-calcified areas (
CONCLUSIONS
CONCLUSIONS
Short telomeres in aortic valves may participate in the development of AS, while concurrently the calcification process seems to promote further local decrease of TL in calcified areas of valves.
Identifiants
pubmed: 33777932
doi: 10.3389/fcell.2021.618335
pmc: PMC7990782
doi:
Types de publication
Journal Article
Langues
eng
Pagination
618335Informations de copyright
Copyright © 2021 Saraieva, Benetos, Labat, Franco-Cereceda, Bäck and Toupance.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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