Bioactive nanotherapeutic trends to combat triple negative breast cancer.

Biomimetic nanoparticles Breast cancer treatment Chemotherapy Membrane cloaked nanoparticles Nanomedicine Nanoparticles Triple negative breast cancer

Journal

Bioactive materials
ISSN: 2452-199X
Titre abrégé: Bioact Mater
Pays: China
ID NLM: 101685294

Informations de publication

Date de publication:
Oct 2021
Historique:
received: 30 10 2020
revised: 27 02 2021
accepted: 28 02 2021
entrez: 29 3 2021
pubmed: 30 3 2021
medline: 30 3 2021
Statut: epublish

Résumé

The management of aggressive breast cancer, particularly, triple negative breast cancer (TNBC) remains a formidable challenge, despite treatment advancement. Although newer therapies such as atezolizumab, olaparib, and sacituzumab can tackle the breast cancer prognosis and/or progression, but achieved limited survival benefit(s). The current research efforts are aimed to develop and implement strategies for improved bioavailability, targetability, reduce systemic toxicity, and enhance therapeutic outcome of FDA-approved treatment regimen. This review presents various nanoparticle technology mediated delivery of chemotherapeutic agent(s) for breast cancer treatment. This article also documents novel strategies to employ cellular and cell membrane cloaked (biomimetic) nanoparticles for effective clinical translation. These technologies offer a safe and active targeting nanomedicine for effective management of breast cancer, especially TNBC.

Identifiants

pubmed: 33778204
doi: 10.1016/j.bioactmat.2021.02.037
pii: S2452-199X(21)00099-2
pmc: PMC7970221
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

3269-3287

Informations de copyright

© 2021 The Authors.

Déclaration de conflit d'intérêts

Authors declare no potential conflict of interests.The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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Auteurs

Pallabita Chowdhury (P)

Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN, USA.

Upasana Ghosh (U)

Department of Biomedical Engineering, School of Engineering, Rutgers University, The State University of New Jersey, Piscataway, NJ, 08854, USA.

Kamalika Samanta (K)

Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN, USA.

Meena Jaggi (M)

Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN, USA.
Department of Immunology and Microbiology, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX, USA.
South Texas Center of Excellence in Cancer Research, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX, USA.

Subhash C Chauhan (SC)

Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN, USA.
Department of Immunology and Microbiology, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX, USA.
South Texas Center of Excellence in Cancer Research, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX, USA.

Murali M Yallapu (MM)

Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN, USA.
Department of Immunology and Microbiology, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX, USA.
South Texas Center of Excellence in Cancer Research, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX, USA.

Classifications MeSH