Bone Strength/Bone Mass Discrepancy in Glucocorticoid-Treated Adult Mice.
1H‐NMR RELAXOMETRY
6‐METHYLPREDNISOLONE
BONE HYDRATION
CORTICAL BONE
TRABECULAR BONE
Journal
JBMR plus
ISSN: 2473-4039
Titre abrégé: JBMR Plus
Pays: England
ID NLM: 101707013
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
received:
23
10
2020
revised:
16
11
2020
accepted:
22
11
2020
entrez:
29
3
2021
pubmed:
30
3
2021
medline:
30
3
2021
Statut:
epublish
Résumé
Glucocorticoids increase bone fragility in patients in a manner that is underestimated by bone mass measurement. This study aimed to determine if the adult mouse could model this bone strength/bone mass discrepancy. Forty-two 13-week-old BALB/cJ mice were randomized into vehicle and glucocorticoid groups, implanted with vehicle or 6-methylprednisolone pellets, and necropsied after 60 and 120 days. Bone strength and bone mass/microarchitecture were assessed at the right central femur (CF; cortical-bone-rich) and sixth lumbar vertebral body (LVB6; trabecular-bone-rich). Bound water (BW) of the whole right femur was analyzed by proton-nuclear magnetic resonance (
Identifiants
pubmed: 33778319
doi: 10.1002/jbm4.10443
pii: JBM410443
pmc: PMC7990143
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e10443Subventions
Organisme : NIAMS NIH HHS
ID : R01 AR063157
Pays : United States
Informations de copyright
© 2020 The Authors. JBMR Plus published by Wiley Periodicals LLC. on behalf of American Society for Bone and Mineral Research.
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