Quantification of Cystic Fibrosis Lung Disease with Radiomics-based CT Scores.

Journal

Radiology. Cardiothoracic imaging
ISSN: 2638-6135
Titre abrégé: Radiol Cardiothorac Imaging
Pays: United States
ID NLM: 101748663

Informations de publication

Date de publication:
Dec 2020
Historique:
received: 31 01 2020
revised: 10 09 2020
accepted: 30 10 2020
entrez: 29 3 2021
pubmed: 30 3 2021
medline: 30 3 2021
Statut: epublish

Résumé

To develop radiomics-based CT scores for assessing lung disease severity and exacerbation risk in adult patients with cystic fibrosis (CF). This two-center retrospective observational study was approved by an institutional ethics committee, and the need for patient consent was waived. A total of 215 outpatients with CF referred for unenhanced follow-up chest CT were evaluated in two different centers between January 2013 and December 2016. After lung segmentation, chest CT scans from center 1 (training cohort, 162 patients [median age, 29 years; interquartile range {IQR}, 24-36 years; 84 men]) were used to build CT scores from 38 extracted CT features, using five different machine learning techniques trained to predict a clinical prognostic score, the Nkam score. The correlations between the developed CT scores, two different clinical prognostic scores (Liou and CF-ABLE), forced expiratory volume in 1 second (FEV In the test cohort, all radiomics-based CT scores showed moderate to strong correlation with the Nkam score ( Radiomics can be used to build automated CT scores that correlate to clinical severity and exacerbation risk in adult patients with CF.Supplemental material is available for this article.See also the commentary by Elicker and Sohn in this issue.© RSNA, 2020.

Identifiants

DOI: 10.1148/ryct.2020200022 PMID: 33778637 PMC: PMC7977785
pubmed: 33778637
doi: 10.1148/ryct.2020200022
pmc: PMC7977785
doi:

Types de publication

Journal Article

Langues

eng

Pagination

e200022

Commentaires et corrections

Type : CommentIn

Informations de copyright

2020 by the Radiological Society of North America, Inc.

Déclaration de conflit d'intérêts

Disclosures of Conflicts of Interest: G.C. disclosed no relevant relationships. E.I.Z. disclosed no relevant relationships. S.B. Activities related to the present article: disclosed no relevant relationships. Activities not related to the present article: disclosed money paid to author’s institution from AstraZeneca for research protocol on chest CT to predict response to Benralizumab; disclosed money paid to author from Boehringer Ingelheim, AstraZeneca, and GSK for lectures, including service on speakers bureaus; disclosed money paid to author from Boehringer Ingelheim for travel/accommodations/meeting expenses unrelated to activities listed. Other relationships: disclosed no relevant relationships. P.R.B. Activities related to the present article: disclosed no relevant relationships. Activities not related to the present article: disclosed money paid to author from Vertex and AstraZeneca for board membership; disclosed money paid to author from AstraZeneca, Boehringer Ingelheim, Chiesi, GSK, Insmed, Novartis, Pfizer, Teva, Vertex, and Zambon for consultancy. Other relationships: disclosed no relevant relationships. R.C. disclosed no relevant relationships. S.D. disclosed no relevant relationships. N.P. Activities related to the present article: disclosed no relevant relationships. Activities not related to the present article: disclosed money paid to author from Artredrone and Easyrescue for board membership; disclosed money paid to author from AstraZeneca and Ipsen for consultancy; disclosed money paid to author from TheraPanacea for employment. Other relationships: disclosed no relevant relationships. C.M. Activities related to the present article: disclosed no relevant relationships. Activities not related to the present article: disclosed money paid to author from Zambon for consultancy; disclosed money paid to author from Chiesi, Vertex, Novartis, ALK, Zambon, and Sunpharma for lectures, including service on speakers bureaus. Other relationships: disclosed no relevant relationships. M.P.R. disclosed no relevant relationships.

Références

J Cyst Fibros. 2017 Mar;16(2):175-185
pubmed: 28040479
J Med Imaging (Bellingham). 2018 Jan;5(1):011020
pubmed: 29487877
Radiology. 1997 Jul;204(1):1-10
pubmed: 9205213
J Cyst Fibros. 2017 Nov;16(6):702-708
pubmed: 28330773
J Cyst Fibros. 2019 May;18(3):396-398
pubmed: 30396836
Pediatr Radiol. 2013 Mar;43(5):558-67
pubmed: 23224105
Lancet Respir Med. 2020 Jan;8(1):65-124
pubmed: 31570318
Eur J Radiol. 2003 Sep;47(3):193-8
pubmed: 12927662
Radiology. 2009 Oct;253(1):223-9
pubmed: 19710003
Radiographics. 2017 Sep-Oct;37(5):1483-1503
pubmed: 28898189
Radiology. 2015 Jul;276(1):258-65
pubmed: 25768672
Eur Radiol. 2018 Dec;28(12):5111-5120
pubmed: 29869171
Chest. 2013 May;143(5):1358-1364
pubmed: 23172242
Eur Respir J. 2016 Jul;48(1):249-52
pubmed: 27230445
Am J Respir Crit Care Med. 2005 Nov 1;172(9):1128-32
pubmed: 16100015
Radiology. 2016 Feb;278(2):563-77
pubmed: 26579733
Am J Respir Crit Care Med. 2012 May 15;185(10):1096-103
pubmed: 22403801
Presse Med. 2017 Jun;46(6 Pt 2):e87-e95
pubmed: 28554720
PLoS One. 2016 Dec 29;11(12):e0166550
pubmed: 28033372
Eur Radiol. 2016 Mar;26(3):780-7
pubmed: 26024847
Pediatr Radiol. 2014 Dec;44(12):1496-506
pubmed: 25164326
Radiol Med. 2007 Feb;112(1):21-30
pubmed: 17310294
Med Phys. 2017 Mar;44(3):1050-1062
pubmed: 28112418
Pediatr Pulmonol. 2014 Dec;49(12):1182-9
pubmed: 24574038
Insights Imaging. 2013 Dec;4(6):787-98
pubmed: 24065629
AJR Am J Roentgenol. 2008 Jun;190(6):1475-80
pubmed: 18492894
Eur Respir J. 2019 Aug 29;54(2):
pubmed: 31196947
Am J Epidemiol. 2001 Feb 15;153(4):345-52
pubmed: 11207152
Radiology. 2004 May;231(2):434-9
pubmed: 15064392
Chest. 2011 Jul;140(1):178-185
pubmed: 21148242
Radiother Oncol. 2015 Mar;114(3):345-50
pubmed: 25746350
AJR Am J Roentgenol. 1997 Aug;169(2):375-80
pubmed: 9242738
J Pediatr. 2004 Jul;145(1):32-8
pubmed: 15238903
Radiology. 2018 Jan;286(1):286-295
pubmed: 28872442
Ann Oncol. 2017 Jun 1;28(6):1191-1206
pubmed: 28168275

Auteurs

Guillaume Chassagnon (G)

Department of Radiology (G.C., S.D., M.P.R.) and Respiratory Medicine and National Cystic Reference Center (P.R.B.), Groupe Hospitalier Cochin-Hotel Dieu, AP-HP, Université Paris Descartes, 27 Rue du Faubourg Saint-Jacques, 75014 Paris, France; Center for Visual Computing, Ecole CentraleSupelec, Grande Voie des Vignes, Chatenay Malabry, France (G.C., E.I.Z., N.P.); U1016 Inserm, Institut Cochin, Paris, France (G.C., P.R.B., C.M., M.P.R.); Radiology Department (S.B.) and Pulmonary Department (R.C.), Hôpital Arnaud de Villeneuve, CHU de Montpellier, Université de Montpellier, Montpellier, France; ERN-Lung CF Network, France (P.R.B., C.M.); and TheraPanacea, Paris-Biotech-Santé, Paris, France (N.P.).
ORCID: 0000-0003-1487-7922

Evangelia I Zacharaki (EI)

Department of Radiology (G.C., S.D., M.P.R.) and Respiratory Medicine and National Cystic Reference Center (P.R.B.), Groupe Hospitalier Cochin-Hotel Dieu, AP-HP, Université Paris Descartes, 27 Rue du Faubourg Saint-Jacques, 75014 Paris, France; Center for Visual Computing, Ecole CentraleSupelec, Grande Voie des Vignes, Chatenay Malabry, France (G.C., E.I.Z., N.P.); U1016 Inserm, Institut Cochin, Paris, France (G.C., P.R.B., C.M., M.P.R.); Radiology Department (S.B.) and Pulmonary Department (R.C.), Hôpital Arnaud de Villeneuve, CHU de Montpellier, Université de Montpellier, Montpellier, France; ERN-Lung CF Network, France (P.R.B., C.M.); and TheraPanacea, Paris-Biotech-Santé, Paris, France (N.P.).
ORCID: 0000-0001-8228-0437

Sébastien Bommart (S)

Department of Radiology (G.C., S.D., M.P.R.) and Respiratory Medicine and National Cystic Reference Center (P.R.B.), Groupe Hospitalier Cochin-Hotel Dieu, AP-HP, Université Paris Descartes, 27 Rue du Faubourg Saint-Jacques, 75014 Paris, France; Center for Visual Computing, Ecole CentraleSupelec, Grande Voie des Vignes, Chatenay Malabry, France (G.C., E.I.Z., N.P.); U1016 Inserm, Institut Cochin, Paris, France (G.C., P.R.B., C.M., M.P.R.); Radiology Department (S.B.) and Pulmonary Department (R.C.), Hôpital Arnaud de Villeneuve, CHU de Montpellier, Université de Montpellier, Montpellier, France; ERN-Lung CF Network, France (P.R.B., C.M.); and TheraPanacea, Paris-Biotech-Santé, Paris, France (N.P.).

Pierre-Régis Burgel (PR)

Department of Radiology (G.C., S.D., M.P.R.) and Respiratory Medicine and National Cystic Reference Center (P.R.B.), Groupe Hospitalier Cochin-Hotel Dieu, AP-HP, Université Paris Descartes, 27 Rue du Faubourg Saint-Jacques, 75014 Paris, France; Center for Visual Computing, Ecole CentraleSupelec, Grande Voie des Vignes, Chatenay Malabry, France (G.C., E.I.Z., N.P.); U1016 Inserm, Institut Cochin, Paris, France (G.C., P.R.B., C.M., M.P.R.); Radiology Department (S.B.) and Pulmonary Department (R.C.), Hôpital Arnaud de Villeneuve, CHU de Montpellier, Université de Montpellier, Montpellier, France; ERN-Lung CF Network, France (P.R.B., C.M.); and TheraPanacea, Paris-Biotech-Santé, Paris, France (N.P.).
ORCID: 0000-0003-0903-9828

Raphael Chiron (R)

Department of Radiology (G.C., S.D., M.P.R.) and Respiratory Medicine and National Cystic Reference Center (P.R.B.), Groupe Hospitalier Cochin-Hotel Dieu, AP-HP, Université Paris Descartes, 27 Rue du Faubourg Saint-Jacques, 75014 Paris, France; Center for Visual Computing, Ecole CentraleSupelec, Grande Voie des Vignes, Chatenay Malabry, France (G.C., E.I.Z., N.P.); U1016 Inserm, Institut Cochin, Paris, France (G.C., P.R.B., C.M., M.P.R.); Radiology Department (S.B.) and Pulmonary Department (R.C.), Hôpital Arnaud de Villeneuve, CHU de Montpellier, Université de Montpellier, Montpellier, France; ERN-Lung CF Network, France (P.R.B., C.M.); and TheraPanacea, Paris-Biotech-Santé, Paris, France (N.P.).

Séverine Dangeard (S)

Department of Radiology (G.C., S.D., M.P.R.) and Respiratory Medicine and National Cystic Reference Center (P.R.B.), Groupe Hospitalier Cochin-Hotel Dieu, AP-HP, Université Paris Descartes, 27 Rue du Faubourg Saint-Jacques, 75014 Paris, France; Center for Visual Computing, Ecole CentraleSupelec, Grande Voie des Vignes, Chatenay Malabry, France (G.C., E.I.Z., N.P.); U1016 Inserm, Institut Cochin, Paris, France (G.C., P.R.B., C.M., M.P.R.); Radiology Department (S.B.) and Pulmonary Department (R.C.), Hôpital Arnaud de Villeneuve, CHU de Montpellier, Université de Montpellier, Montpellier, France; ERN-Lung CF Network, France (P.R.B., C.M.); and TheraPanacea, Paris-Biotech-Santé, Paris, France (N.P.).
ORCID: 0000-0002-6503-7336

Nikos Paragios (N)

Department of Radiology (G.C., S.D., M.P.R.) and Respiratory Medicine and National Cystic Reference Center (P.R.B.), Groupe Hospitalier Cochin-Hotel Dieu, AP-HP, Université Paris Descartes, 27 Rue du Faubourg Saint-Jacques, 75014 Paris, France; Center for Visual Computing, Ecole CentraleSupelec, Grande Voie des Vignes, Chatenay Malabry, France (G.C., E.I.Z., N.P.); U1016 Inserm, Institut Cochin, Paris, France (G.C., P.R.B., C.M., M.P.R.); Radiology Department (S.B.) and Pulmonary Department (R.C.), Hôpital Arnaud de Villeneuve, CHU de Montpellier, Université de Montpellier, Montpellier, France; ERN-Lung CF Network, France (P.R.B., C.M.); and TheraPanacea, Paris-Biotech-Santé, Paris, France (N.P.).
ORCID: 0000-0002-9668-4763

Clémence Martin (C)

Department of Radiology (G.C., S.D., M.P.R.) and Respiratory Medicine and National Cystic Reference Center (P.R.B.), Groupe Hospitalier Cochin-Hotel Dieu, AP-HP, Université Paris Descartes, 27 Rue du Faubourg Saint-Jacques, 75014 Paris, France; Center for Visual Computing, Ecole CentraleSupelec, Grande Voie des Vignes, Chatenay Malabry, France (G.C., E.I.Z., N.P.); U1016 Inserm, Institut Cochin, Paris, France (G.C., P.R.B., C.M., M.P.R.); Radiology Department (S.B.) and Pulmonary Department (R.C.), Hôpital Arnaud de Villeneuve, CHU de Montpellier, Université de Montpellier, Montpellier, France; ERN-Lung CF Network, France (P.R.B., C.M.); and TheraPanacea, Paris-Biotech-Santé, Paris, France (N.P.).

Marie-Pierre Revel (MP)

Department of Radiology (G.C., S.D., M.P.R.) and Respiratory Medicine and National Cystic Reference Center (P.R.B.), Groupe Hospitalier Cochin-Hotel Dieu, AP-HP, Université Paris Descartes, 27 Rue du Faubourg Saint-Jacques, 75014 Paris, France; Center for Visual Computing, Ecole CentraleSupelec, Grande Voie des Vignes, Chatenay Malabry, France (G.C., E.I.Z., N.P.); U1016 Inserm, Institut Cochin, Paris, France (G.C., P.R.B., C.M., M.P.R.); Radiology Department (S.B.) and Pulmonary Department (R.C.), Hôpital Arnaud de Villeneuve, CHU de Montpellier, Université de Montpellier, Montpellier, France; ERN-Lung CF Network, France (P.R.B., C.M.); and TheraPanacea, Paris-Biotech-Santé, Paris, France (N.P.).

Classifications MeSH