Functional alterations by a subgroup of neonicotinoid pesticides in human dopaminergic neurons.


Journal

Archives of toxicology
ISSN: 1432-0738
Titre abrégé: Arch Toxicol
Pays: Germany
ID NLM: 0417615

Informations de publication

Date de publication:
06 2021
Historique:
received: 07 12 2020
accepted: 17 03 2021
pubmed: 30 3 2021
medline: 8 1 2022
entrez: 29 3 2021
Statut: ppublish

Résumé

Neonicotinoid pesticides, originally developed to target the insect nervous system, have been reported to interact with human receptors and to activate rodent neurons. Therefore, we evaluated in how far these compounds may trigger signaling in human neurons, and thus, affect the human adult or developing nervous system. We used SH-SY5Y neuroblastoma cells as established model of nicotinic acetylcholine receptor (nAChR) signaling. In parallel, we profiled dopaminergic neurons, generated from LUHMES neuronal precursor cells, as novel system to study nAChR activation in human post-mitotic neurons. Changes of the free intracellular Ca

Identifiants

pubmed: 33778899
doi: 10.1007/s00204-021-03031-1
pii: 10.1007/s00204-021-03031-1
pmc: PMC8166715
doi:

Substances chimiques

Neonicotinoids 0
Pesticides 0
Receptors, Nicotinic 0
Calcium SY7Q814VUP

Types de publication

Comparative Study Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2081-2107

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Auteurs

Dominik Loser (D)

NMI Natural and Medical Sciences Institute at the University of Tübingen, 72770, Reutlingen, Germany.
NMI TT GmbH, 72770, Reutlingen, Germany.
In Vitro Toxicology and Biomedicine, Department Inaugurated by the Doerenkamp-Zbinden Foundation, University of Konstanz, Universitaetsstr. 10, 78457, Konstanz, Germany.

Maria G Hinojosa (MG)

Department of Biochemistry and Biophysics, Stockholm University, 106 91, Stockholm, Sweden.

Jonathan Blum (J)

In Vitro Toxicology and Biomedicine, Department Inaugurated by the Doerenkamp-Zbinden Foundation, University of Konstanz, Universitaetsstr. 10, 78457, Konstanz, Germany.

Jasmin Schaefer (J)

NMI Natural and Medical Sciences Institute at the University of Tübingen, 72770, Reutlingen, Germany.
NMI TT GmbH, 72770, Reutlingen, Germany.

Markus Brüll (M)

In Vitro Toxicology and Biomedicine, Department Inaugurated by the Doerenkamp-Zbinden Foundation, University of Konstanz, Universitaetsstr. 10, 78457, Konstanz, Germany.

Ylva Johansson (Y)

Department of Biochemistry and Biophysics, Stockholm University, 106 91, Stockholm, Sweden.

Ilinca Suciu (I)

In Vitro Toxicology and Biomedicine, Department Inaugurated by the Doerenkamp-Zbinden Foundation, University of Konstanz, Universitaetsstr. 10, 78457, Konstanz, Germany.

Karin Grillberger (K)

Department of Pharmaceutical Sciences, University of Vienna, Vienna, Austria.

Timm Danker (T)

NMI Natural and Medical Sciences Institute at the University of Tübingen, 72770, Reutlingen, Germany.
NMI TT GmbH, 72770, Reutlingen, Germany.

Clemens Möller (C)

Life Sciences Faculty, Albstadt-Sigmaringen University, 72488, Sigmaringen, Germany.

Iain Gardner (I)

CERTARA UK Limited, Simcyp Division, Level 2-Acero, 1 Concourse Way, Sheffield, S1 2BJ, UK.

Gerhard F Ecker (GF)

Department of Pharmaceutical Sciences, University of Vienna, Vienna, Austria.

Susanne H Bennekou (SH)

Technical University of Denmark, Kongens Lyngby, Denmark.

Anna Forsby (A)

Department of Biochemistry and Biophysics, Stockholm University, 106 91, Stockholm, Sweden.

Udo Kraushaar (U)

NMI Natural and Medical Sciences Institute at the University of Tübingen, 72770, Reutlingen, Germany.

Marcel Leist (M)

In Vitro Toxicology and Biomedicine, Department Inaugurated by the Doerenkamp-Zbinden Foundation, University of Konstanz, Universitaetsstr. 10, 78457, Konstanz, Germany. marcel.leist@uni-konstanz.de.

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