Functional alterations by a subgroup of neonicotinoid pesticides in human dopaminergic neurons.
Calcium
/ metabolism
Cell Line
Cell Line, Tumor
Dopaminergic Neurons
/ drug effects
Dose-Response Relationship, Drug
Humans
Neonicotinoids
/ administration & dosage
Neuroblastoma
/ metabolism
Patch-Clamp Techniques
Pesticides
/ toxicity
Receptors, Nicotinic
/ drug effects
Signal Transduction
/ drug effects
Desensitization
Live-cell calcium imaging
Molecular docking
Neurotoxicity
Nicotine
Journal
Archives of toxicology
ISSN: 1432-0738
Titre abrégé: Arch Toxicol
Pays: Germany
ID NLM: 0417615
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
received:
07
12
2020
accepted:
17
03
2021
pubmed:
30
3
2021
medline:
8
1
2022
entrez:
29
3
2021
Statut:
ppublish
Résumé
Neonicotinoid pesticides, originally developed to target the insect nervous system, have been reported to interact with human receptors and to activate rodent neurons. Therefore, we evaluated in how far these compounds may trigger signaling in human neurons, and thus, affect the human adult or developing nervous system. We used SH-SY5Y neuroblastoma cells as established model of nicotinic acetylcholine receptor (nAChR) signaling. In parallel, we profiled dopaminergic neurons, generated from LUHMES neuronal precursor cells, as novel system to study nAChR activation in human post-mitotic neurons. Changes of the free intracellular Ca
Identifiants
pubmed: 33778899
doi: 10.1007/s00204-021-03031-1
pii: 10.1007/s00204-021-03031-1
pmc: PMC8166715
doi:
Substances chimiques
Neonicotinoids
0
Pesticides
0
Receptors, Nicotinic
0
Calcium
SY7Q814VUP
Types de publication
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2081-2107Références
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