Ubiquitin-dependent regulation of transcription in development and disease.
RNA polymerase II
histone modification
transcription
ubiquitin
Journal
EMBO reports
ISSN: 1469-3178
Titre abrégé: EMBO Rep
Pays: England
ID NLM: 100963049
Informations de publication
Date de publication:
07 04 2021
07 04 2021
Historique:
revised:
29
11
2020
received:
11
06
2020
accepted:
01
03
2021
pubmed:
30
3
2021
medline:
1
6
2021
entrez:
29
3
2021
Statut:
ppublish
Résumé
Transcription is an elaborate process that is required to establish and maintain the identity of the more than two hundred cell types of a metazoan organism. Strict regulation of gene expression is therefore vital for tissue formation and homeostasis. An accumulating body of work found that ubiquitylation of histones, transcription factors, or RNA polymerase II is crucial for ensuring that transcription occurs at the right time and place during development. Here, we will review principles of ubiquitin-dependent control of gene expression and discuss how breakdown of these regulatory circuits leads to a wide array of human diseases.
Identifiants
pubmed: 33779035
doi: 10.15252/embr.202051078
pmc: PMC8025022
doi:
Substances chimiques
Histones
0
Ubiquitin
0
RNA Polymerase II
EC 2.7.7.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e51078Subventions
Organisme : NIGMS NIH HHS
ID : F32 GM120956
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States
Organisme : NIGMS NIH HHS
ID : F32GM120956
Pays : United States
Informations de copyright
© 2021 The Authors.
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