Radiohistogenomics of pediatric low-grade neuroepithelial tumors.
BRAF p.V600E
Imaging
KIAA1549-BRAF fusion
MAPK
MRI
Pediatric low-grade glioma (PLGG)
Pediatric low-grade neuroepithelial tumors (PLGNTs)
Radiology
Journal
Neuroradiology
ISSN: 1432-1920
Titre abrégé: Neuroradiology
Pays: Germany
ID NLM: 1302751
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
received:
03
12
2020
accepted:
10
03
2021
pubmed:
30
3
2021
medline:
30
9
2021
entrez:
29
3
2021
Statut:
ppublish
Résumé
In addition to histology, genetic alteration is now required to classify many central nervous system (CNS) tumors according to the most recent World Health Organization CNS tumor classification scheme. Although that is still not the case for classifying pediatric low-grade neuroepithelial tumors (PLGNTs), genetic and molecular features are increasingly being used for making treatment decisions. This approach has become a standard clinical practice in many specialized pediatric cancer centers and will likely be more widely practiced in the near future. This paradigm shift in the management of PLGNTs necessitates better understanding of how genetic alterations influence histology and imaging characteristics of individual PLGNT phenotypes. The complex association of genetic alterations with histology, clinical, and imaging of each phenotype of the extremely heterogeneous PLGNT family has been addressed in a holistic approach in this up-to-date review article. A new imaging stratification scheme has been proposed based on tumor morphology, location, histology, and genetics. Imaging characteristics of each PLGNT entity are also depicted in light of histology and genetics. This article reviews the association of specific genetic alteration with location, histology, imaging, and prognosis of a specific tumor of the PLGNT family and how that information can be used for better imaging of these tumors.
Identifiants
pubmed: 33779771
doi: 10.1007/s00234-021-02691-1
pii: 10.1007/s00234-021-02691-1
pmc: PMC8295117
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1185-1213Subventions
Organisme : American Lebanese Syrian Associated Charities
ID : NA
Informations de copyright
© 2021. The Author(s).
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