The presence of Prevotella melaninogenica within tissue and preliminary study on its role in the pathogenesis of oral lichen planus.
Prevotella melaninogenica
NF-κB pathway
Oral lichen planus
invasion
transcription
Journal
Oral diseases
ISSN: 1601-0825
Titre abrégé: Oral Dis
Pays: Denmark
ID NLM: 9508565
Informations de publication
Date de publication:
Sep 2022
Sep 2022
Historique:
revised:
03
03
2021
received:
11
01
2021
accepted:
22
03
2021
pubmed:
30
3
2021
medline:
12
8
2022
entrez:
29
3
2021
Statut:
ppublish
Résumé
Oral lichen planus (OLP) is a chronic inflammatory disease that occurs in the oral mucosa with characteristic white striations lesions, recurrent erosions, and pains. The etiology and pathogenesis of OLP are still unclear. We analyzed the bacterial community structure of buccal mucosa in patients with OLP and normal controls by high-throughput sequencing. Fluorescence in situ hybridization (FISH) was used to detect Prevotella melaninogenica (P. melaninogenica) in 13 OLP samples and 10 controls. The amounts of P. melaninogenica in OLP buccal mucosa and the expression of inflammatory cytokines in co-culture of mouse-derived macrophages with P. melaninogenica were detected by RT-qPCR. The P. melaninogenica was more abundant in OLP than in healthy controls, and the differences were significant at the level of the phylum, family, genus, and species (p < .05). FISH showed that P. melaninogenica can invade the epithelium and even the lamina propria of OLP, while no invasion was found in the normal mucosa. Prevotella melaninogenica can adhere to and invade macrophages and then activate the transcription of IL-1β, IL-6, and TNF-α in NF-κB signaling pathway. Prevotella melaninogenica may be involved in the pathogenic process of OLP, and its specific mechanism deserves further study.
Substances chimiques
Cytokines
0
Types de publication
Journal Article
Langues
eng
Pagination
1580-1590Subventions
Organisme : Natural Science Foundation of China
ID : 8
Organisme : CSRD VA
ID : 1
Pays : United States
Organisme : Natural Science Foundation of China
ID : 870764
Organisme : Natural Science Foundation of China
ID : 81000438
Organisme : CSRD VA
ID : 1
Pays : United States
Informations de copyright
© 2021 Wiley Periodicals LLC.
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