Development of Respercise® a Digital Application for Standardizing Home Exercise in COPD Clinical Trials.
clinical trials
copd
digital applications
exercise
physical activity
usability
Journal
Chronic obstructive pulmonary diseases (Miami, Fla.)
ISSN: 2372-952X
Titre abrégé: Chronic Obstr Pulm Dis
Pays: United States
ID NLM: 101635411
Informations de publication
Date de publication:
27 Apr 2021
27 Apr 2021
Historique:
pubmed:
30
3
2021
medline:
30
3
2021
entrez:
29
3
2021
Statut:
ppublish
Résumé
Pulmonary rehabilitation (PR) is an important therapy for patients with chronic obstructive pulmonary disease (COPD), yet uptake remains low. Intervention strategies which recapitulate the benefits of PR are, therefore, needed and digital, home-based therapies present opportunity in this space. Digital therapies also potentially offer an opportunity to standardize PR in clinical trials for new COPD therapies. We aimed to create a digital application (app), Respercise Feedback from clinical trial participants was positive; 97% of respondents liked the app. A total of 88% of participants reported that it was easy to fit the exercises into their daily routine, and there was over 90% adherence for entering daily step counts. Notably, on day 90 both females and males using Respercise alone demonstrated a 2.22- and 2.27-seconds improvement in time for 5-repetition sit-to-stand tests respectively, above the 1.7 second threshold that is considered clinically meaningful in COPD. Respercise can be successfully deployed in clinical trials, offering the opportunity for standardization of exercise in clinical trials and, with further development, could have wider reach as a home-based intervention for individuals with COPD.
Sections du résumé
BACKGROUND
BACKGROUND
Pulmonary rehabilitation (PR) is an important therapy for patients with chronic obstructive pulmonary disease (COPD), yet uptake remains low. Intervention strategies which recapitulate the benefits of PR are, therefore, needed and digital, home-based therapies present opportunity in this space. Digital therapies also potentially offer an opportunity to standardize PR in clinical trials for new COPD therapies.
AIMS AND METHODS
OBJECTIVE
We aimed to create a digital application (app), Respercise
RESULTS
RESULTS
Feedback from clinical trial participants was positive; 97% of respondents liked the app. A total of 88% of participants reported that it was easy to fit the exercises into their daily routine, and there was over 90% adherence for entering daily step counts. Notably, on day 90 both females and males using Respercise alone demonstrated a 2.22- and 2.27-seconds improvement in time for 5-repetition sit-to-stand tests respectively, above the 1.7 second threshold that is considered clinically meaningful in COPD.
CONCLUSIONS
CONCLUSIONS
Respercise can be successfully deployed in clinical trials, offering the opportunity for standardization of exercise in clinical trials and, with further development, could have wider reach as a home-based intervention for individuals with COPD.
Identifiants
pubmed: 33780603
doi: 10.15326/jcopdf.2020.0194
pmc: PMC8237981
doi:
Types de publication
Journal Article
Langues
eng
Pagination
269-276Subventions
Organisme : GlaxoSmithKline
Pays : United States
Informations de copyright
JCOPDF © 2021.
Références
Thorax. 2013 Nov;68(11):1015-20
pubmed: 23783372
Health Educ Res. 2010 Aug;25(4):585-95
pubmed: 19897515
COPD. 2015 Apr;12(2):144-53
pubmed: 24984085
J Med Internet Res. 2005 Mar 31;7(1):e11
pubmed: 15829473
J Electromyogr Kinesiol. 2014 Dec;24(6):815-26
pubmed: 25455254
Ann Am Thorac Soc. 2019 Jan;16(1):55-57
pubmed: 30592449
Annu Rev Public Health. 2009;30:273-92
pubmed: 19296777
Chronic Obstr Pulm Dis. 2020 Apr;7(2):73-75
pubmed: 32324976
Contemp Clin Trials. 2016 Jan;46:18-29
pubmed: 26597414
Respir Med. 2012 Apr;106(4):522-30
pubmed: 22118987
Popul Health Manag. 2018 Feb;21(1):32-39
pubmed: 28586257
Eur Respir J. 2017 May 25;49(5):
pubmed: 28546268
BMJ Open. 2015 Aug 25;5(8):e008055
pubmed: 26307616
Am J Respir Crit Care Med. 2019 Aug 15;200(4):511-513
pubmed: 30978302
Int J Chron Obstruct Pulmon Dis. 2013;8:317-27
pubmed: 23874093
Thorax. 2013 Sep;68 Suppl 2:ii1-30
pubmed: 23880483