Establishment of a collection of human pluripotent stem cell lines (iPSC) from mesenchymal stem cells (MSC) from three healthy elderly donors.
Journal
Stem cell research
ISSN: 1876-7753
Titre abrégé: Stem Cell Res
Pays: England
ID NLM: 101316957
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
received:
17
10
2020
revised:
17
02
2021
accepted:
14
03
2021
pubmed:
30
3
2021
medline:
1
7
2021
entrez:
29
3
2021
Statut:
ppublish
Résumé
The study of molecular mechanism driving osteoarticular diseases like osteoarthritis or osteoporosis is impaired by the low accessibility to mesenchymal stem cells (MSC) from healthy donors (HD) for differential multi-omics analysis. Advances in cell reprogramming have, however, provided both a new source of human cells for laboratory research and a strategy to erase epigenetic marks involved in cell identity and the development of diseases. To unravel the pathological signatures on the MSC at the origin of cellular drifts during the formation of bone and cartilage, we previously developed iPSC from MSC of osteoarthritis donors. Here we present the derivation of three iPSCs from healthy age matched donors to model the disease and further identify (epi)genomic signatures of the pathology.
Identifiants
pubmed: 33780731
pii: S1873-5061(21)00143-4
doi: 10.1016/j.scr.2021.102297
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
102297Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.