Discrepancies of polygenic effects on symptom dimensions between adolescents and adults with ADHD.

Adolescent Adult Attention Attention Deficit Disorder with Hyperactivity / genetics Gray Matter Humans Impulsive Behavior Multifactorial Inheritance / genetics

Journal

Psychiatry research. Neuroimaging
ISSN: 1872-7506
Titre abrégé: Psychiatry Res Neuroimaging
Pays: Netherlands
ID NLM: 101723001

Informations de publication

Date de publication:
30 05 2021
Historique:
received: 18 03 2020
revised: 12 03 2021
accepted: 18 03 2021
pubmed: 30 3 2021
medline: 21 5 2021
entrez: 29 3 2021
Statut: ppublish

Résumé

A significant proportion of individuals with attention-deficit/hyperactivity disorder (ADHD) show persistence into adulthood. The genetic and neural correlates of ADHD in adolescents versus adults remain poorly characterized. We investigated ADHD polygenic risk score (PRS) in relation to previously identified gray matter (GM) patterns, neurocognitive, and symptom findings in the same ADHD sample (462 adolescents & 422 adults from the NeuroIMAGE and IMpACT cohorts). Significant effects of ADHD PRS were found on hyperactivity and impulsivity symptoms in adolescents, hyperactivity symptom in adults, but not GM volume components. A distinct PRS effect between adolescents and adults on individual ADHD symptoms is suggested.

Identifiants

DOI: 10.1016/j.pscychresns.2021.111282 PMID: 33780745 PMC: PMC8058322
pubmed: 33780745
pii: S0925-4927(21)00034-2
doi: 10.1016/j.pscychresns.2021.111282
pmc: PMC8058322
mid: NIHMS1687793
pii:
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

111282

Subventions

Organisme : NIMH NIH HHS
ID : R01 MH062873
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH106655
Pays : United States

Informations de copyright

Copyright © 2021. Published by Elsevier B.V.

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Auteurs

Wenhao Jiang (W)

Department of Psychology, Georgia State University, United States; Department of Psychosomatics and Psychiatry, Zhongda Hospital, Institute of Psychosomatics, Medical School, Southeast University, Nanjing, China.

Kelly Rootes-Murdy (K)

Department of Psychology, Georgia State University, United States. Electronic address: krootesmurdy1@student.gsu.edu.

Kuaikuai Duan (K)

School of Electrical and Computer Engineering, Georgia Institute of Technology, USA.

Gido Schoenmacker (G)

Department of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands; Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands.

Pieter J Hoekstra (PJ)

University of Groningen, University Medical Center Groningen, Department of Psychiatry, Groningen, the Netherlands.

Catharina A Hartman (CA)

University of Groningen, University Medical Center Groningen, Department of Psychiatry, Groningen, the Netherlands.

Jaap Oosterlaan (J)

Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Emma Neuroscience Group, department of Pediatrics, Amsterdam Reproduction & Development, Amsterdam, The Netherlands; Vrije Universiteit, Clinical Neuropsychology section, Van der Boechortstraat 7, 1081 BT Amsterdam, Netherlands.

Dirk Heslenfeld (D)

Vrije Universiteit, Clinical Neuropsychology section, Van der Boechortstraat 7, 1081 BT Amsterdam, Netherlands.

Barbara Franke (B)

Department of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands; Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands.

Emma Sprooten (E)

Department of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands; Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands.

Jan Buitelaar (J)

Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands.

Alejandro Arias-Vasquez (A)

Department of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands; Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands.

Jingyu Liu (J)

Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology and Emory University, USA; Department of Computer Science, Georgia State University, USA.

Jessica A Turner (JA)

Department of Psychology, Georgia State University, United States; Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology and Emory University, USA; Neuroscience Institute, Georgia State University, USA.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adolescent › Discrepancies of polygenic effects on symptom...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Discrepancies of polygenic effects on symptom...
questionsmedicales.fr › Phénomènes psychologiques › Attention › Discrepancies of polygenic effects on symptom...
questionsmedicales.fr › Troubles mentaux › Troubles du développement neurologique › Troubles déficitaires de l'attention et du comportement perturbateur › Trouble déficitaire de l'attention avec hyperactivité › Discrepancies of polygenic effects on symptom...
questionsmedicales.fr › Système nerveux › Système nerveux central › Moelle spinale › Substance grise › Discrepancies of polygenic effects on symptom...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Discrepancies of polygenic effects on symptom...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Comportement › Comportement impulsif › Discrepancies of polygenic effects on symptom...
questionsmedicales.fr › Phénomènes génétiques › Modes de transmission héréditaire › Hérédité multifactorielle › Discrepancies of polygenic effects on symptom...