Escape of SARS-CoV-2 501Y.V2 from neutralization by convalescent plasma.


Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
05 2021
Historique:
received: 21 01 2021
accepted: 18 03 2021
pubmed: 30 3 2021
medline: 12 5 2021
entrez: 29 3 2021
Statut: ppublish

Résumé

SARS-CoV-2 variants of concern (VOC) have arisen independently at multiple locations

Identifiants

pubmed: 33780970
doi: 10.1038/s41586-021-03471-w
pii: 10.1038/s41586-021-03471-w
pmc: PMC9867906
mid: NIHMS1863674
doi:

Substances chimiques

Antibodies, Neutralizing 0
Antibodies, Viral 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

142-146

Subventions

Organisme : NIDA NIH HHS
ID : DP2 DA040254
Pays : United States

Investigateurs

Shareef Abrahams (S)
Luiz Carlos Junior Alcantara (LCJ)
Arghavan Alisoltani-Dehkordi (A)
Mushal Allam (M)
Jinal N Bhiman (JN)
Mary-Ann Davies (MA)
Deelan Doolabh (D)
Susan Engelbrecht (S)
Vagner Fonseca (V)
Marta Giovanetti (M)
Allison J Glass (AJ)
Adam Godzik (A)
Dominique Goedhals (D)
Diana Hardie (D)
Marvin Hsiao (M)
Arash Iranzadeh (A)
Arshad Ismail (A)
Stephen Korsman (S)
Sergei L Kosakovsky Pond (SLK)
Oluwakemi Laguda-Akingba (O)
Jose Lourenco (J)
Gert Marais (G)
Darren Martin (D)
Caroline Maslo (C)
Koleka Mlisana (K)
Thabo Mohale (T)
Nokukhanya Msomi (N)
Innocent Mudau (I)
Francesco Petruccione (F)
Wolfgang Preiser (W)
Emmanuel James San (EJ)
Bryan Trevor Sewell (BT)
Lynn Tyers (L)
Gert Van Zyl (G)
Anne von Gottberg (A)
Sibongile Walaza (S)
Steven Weaver (S)
Constantinos Kurt Wibmer (CK)
Carolyn Williamson (C)
Denis York (D)
Moherndran Archary (M)
Kaylesh J Dullabh (KJ)
Philip Goulder (P)
Sashin Harilall (S)
Guy Harling (G)
Rohen Harrichandparsad (R)
Kobus Herbst (K)
Prakash Jeena (P)
Thandeka Khoza (T)
Nigel Klein (N)
Henrik Kløverpris (H)
Alasdair Leslie (A)
Rajhmun Madansein (R)
Mohlopheni Marakalala (M)
Matilda Mazibuko (M)
Mosa Moshabela (M)
Ntombifuthi Mthabela (N)
Kogie Naidoo (K)
Zaza Ndhlovu (Z)
Thumbi Ndung'u (T)
Kennedy Nyamande (K)
Nesri Padayatchi (N)
Vinod Patel (V)
Dirhona Ramjit (D)
Hylton Rodel (H)
Theresa Smit (T)
Adrie Steyn (A)
Emily Wong (E)

Références

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Faria, N. R. et al. Genomics and epidemiology of a novel SARS-CoV-2 lineage in Manaus, Brazil. Preprint at https://doi.org/10.1101/2021.02.26.21252554 (2021).
Madhi, S. A. et al. Efficacy of the ChAdOx1 nCoV-19 COVID-19 vaccine against the B.1.351 variant. N. Engl. J. Med. https://doi.org/10.1056/NEJMoa2102214 (2021).
doi: 10.1056/NEJMoa2102214 pubmed: 33725432 pmcid: 7993410
Piccoli, L. et al. Mapping neutralizing and immunodominant sites on the SARS-CoV-2 spike receptor-binding domain by structure-guided high-resolution serology. Cell 183, 1024–1042 (2020).
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McCallum, M. et al. N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2. Cell https://doi.org/10.1016/j.cell.2021.03.028 (2021).
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Auteurs

Sandile Cele (S)

Africa Health Research Institute, Durban, South Africa.
School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.

Inbal Gazy (I)

School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.
KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.
Department of Biochemistry and Molecular Biology, The Institute for Medical Research Israel-Canada, Hadassah Medical School, The Hebrew University of Jerusalem, Jerusalem, Israel.

Laurelle Jackson (L)

Africa Health Research Institute, Durban, South Africa.

Shi-Hsia Hwa (SH)

Africa Health Research Institute, Durban, South Africa.
Division of Infection and Immunity, University College London, London, UK.

Houriiyah Tegally (H)

KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.

Gila Lustig (G)

Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa.

Jennifer Giandhari (J)

KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.

Sureshnee Pillay (S)

KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.

Eduan Wilkinson (E)

KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.

Yeshnee Naidoo (Y)

KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.

Farina Karim (F)

Africa Health Research Institute, Durban, South Africa.
School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.

Yashica Ganga (Y)

Africa Health Research Institute, Durban, South Africa.

Khadija Khan (K)

Africa Health Research Institute, Durban, South Africa.

Mallory Bernstein (M)

Africa Health Research Institute, Durban, South Africa.

Alejandro B Balazs (AB)

Ragon Institute of MGH, Harvard and MIT, Cambridge, MA, USA.

Bernadett I Gosnell (BI)

Department of Infectious Diseases, Nelson R. Mandela School of Clinical Medicine, University of KwaZulu-Natal, Durban, South Africa.

Willem Hanekom (W)

Africa Health Research Institute, Durban, South Africa.
Division of Infection and Immunity, University College London, London, UK.

Mahomed-Yunus S Moosa (MS)

Department of Infectious Diseases, Nelson R. Mandela School of Clinical Medicine, University of KwaZulu-Natal, Durban, South Africa.

Richard J Lessells (RJ)

KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.
Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa.

Tulio de Oliveira (T)

KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa. deoliveira@ukzn.ac.za.
Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa. deoliveira@ukzn.ac.za.
Department of Global Health, University of Washington, Seattle, WA, USA. deoliveira@ukzn.ac.za.

Alex Sigal (A)

Africa Health Research Institute, Durban, South Africa. alex.sigal@ahri.org.
School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa. alex.sigal@ahri.org.
Max Planck Institute for Infection Biology, Berlin, Germany. alex.sigal@ahri.org.

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