Carbon Monoxide: from Poison to Clinical Trials.

Carbon Monoxide Circadian Clocks Gasotransmitters Heme Oxygenase (Decyclizing) Poisons
circadian rhythm clock gasotransmitters heme neuroprotection sleep/wake

Journal

Trends in pharmacological sciences
ISSN: 1873-3735
Titre abrégé: Trends Pharmacol Sci
Pays: England
ID NLM: 7906158

Informations de publication

Date de publication:
05 2021
Historique:
received: 22 10 2020
revised: 17 02 2021
accepted: 24 02 2021
pubmed: 31 3 2021
medline: 1 9 2021
entrez: 30 3 2021
Statut: ppublish

Résumé

Every cell has a highly sophisticated system for regulating heme levels, which is particularly important with regard to turnover. Heme degradation generates CO and while CO has long been viewed as a metabolic waste product, and at higher concentrations cellularly lethal, we now know that CO is an indispensable gasotransmitter that participates in fundamental physiological processes necessary for survival. Irrefutable preclinical data have resulted in concerted efforts to develop CO as a safe and effective therapeutic agent, but against this notion lies dogma that CO is a poison, especially to the brain. The emergence of this debate is discussed here highlighting the neuroprotective properties of CO through its role on the central circadian clock and ongoing strategies being developed for CO administration for clinical use.

Identifiants

DOI: 10.1016/j.tips.2021.02.003 PMID: 33781582 PMC: PMC8134950
pubmed: 33781582
pii: S0165-6147(21)00041-9
doi: 10.1016/j.tips.2021.02.003
pmc: PMC8134950
mid: NIHMS1688325
pii:
doi:

Substances chimiques

Gasotransmitters 0
Poisons 0
Carbon Monoxide 7U1EE4V452
Heme Oxygenase (Decyclizing) EC 1.14.14.18

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

329-339

Subventions

Organisme : NINDS NIH HHS
ID : R01 NS073613
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS103161
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS092652
Pays : United States
Organisme : NIDDK NIH HHS
ID : R44 DK111260
Pays : United States
Organisme : NIGMS NIH HHS
ID : R43 GM125430
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK119202
Pays : United States
Organisme : NIDDK NIH HHS
ID : R41 DK123933
Pays : United States
Organisme : NHLBI NIH HHS
ID : R41 HL150889
Pays : United States

Informations de copyright

Copyright © 2021 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Interests Leo Otterbein is a scientific advisor for Hillhurst Biopharmaceuticals.

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Auteurs

Rosalba Siracusa (R)

Department of Surgery, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA, 02115, USA; Department of Chemical, Biological, Pharmaceutical and Environmental Science, University of Messina, Messina, Italy, 98166.

Alexa Schaufler (A)

Department of Surgery, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA, 02115, USA.

Vittorio Calabrese (V)

Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.

Patrick M Fuller (PM)

Department of Neurology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA, 02115, USA; Department of Neurological Surgery, University of California Davis Health, Sacramento, CA 95817, USA.

Leo E Otterbein (LE)

Department of Surgery, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA, 02115, USA. Electronic address: lotterbe@bidmc.harvard.edu.

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Classifications MeSH

questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Oxydes › Monoxyde de carbone › Carbon Monoxide: from Poison to Clinical Trials.
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes chronobiologiques › Périodicité › Horloges biologiques › Horloges circadiennes › Carbon Monoxide: from Poison to Clinical Trials.
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Gazotransmetteurs › Carbon Monoxide: from Poison to Clinical Trials.
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxygénases › Mixed function oxygenases › Heme oxygenase (decyclizing) › Carbon Monoxide: from Poison to Clinical Trials.
questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Noxas › Toxiques › Carbon Monoxide: from Poison to Clinical Trials.