Steroidogenic cytochrome P450 17A1 structure and function.

Breast Neoplasms / metabolism Catalytic Domain Cushing Syndrome / metabolism Female Glioblastoma / metabolism Humans Hydroxylation Male Prostatic Neoplasms / metabolism Steroid 17-alpha-Hydroxylase / chemistry Substrate Specificity
Cancer Crystallography Cushing's syndrome Cytochrome P450 17A1 Mechanism Prostate

Journal

Molecular and cellular endocrinology
ISSN: 1872-8057
Titre abrégé: Mol Cell Endocrinol
Pays: Ireland
ID NLM: 7500844

Informations de publication

Date de publication:
15 05 2021
Historique:
received: 28 10 2020
revised: 01 03 2021
accepted: 22 03 2021
pubmed: 31 3 2021
medline: 1 12 2021
entrez: 30 3 2021
Statut: ppublish

Résumé

Cytochrome P450 17A1 (CYP17A1) is a critical steroidogenic enzyme, essential for producing glucocorticoids and sex hormones. This review discusses the complex activity of CYP17A1, looking at its role in both the classical and backdoor steroidogenic pathways and the complex chemistry it carries out to perform both a hydroxylation reaction and a carbon-carbon cleavage, or lyase reaction. Functional and structural investigations have informed our knowledge of these two reactions. This review focuses on a few specific aspects of this discussion: the identities of reaction intermediates, the coordination of hydroxylation and lyase reactions, the effects of cytochrome b

Identifiants

DOI: 10.1016/j.mce.2021.111261 PMID: 33781841 PMC: PMC8087655
pubmed: 33781841
pii: S0303-7207(21)00105-2
doi: 10.1016/j.mce.2021.111261
pmc: PMC8087655
mid: NIHMS1692438
pii:
doi:

Substances chimiques

CYP17A1 protein, human EC 1.14.14.19
Steroid 17-alpha-Hydroxylase EC 1.14.14.19

Types de publication

Journal Article Research Support, N.I.H., Extramural Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

111261

Subventions

Organisme : NIGMS NIH HHS
ID : R37 GM076343
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007767
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM140223
Pays : United States

Informations de copyright

Copyright © 2021 Elsevier B.V. All rights reserved.

Références

Biochem Biophys Res Commun. 2014 Jan 3;443(1):179-84
pubmed: 24299954
Clin Endocrinol (Oxf). 2017 Nov;87(5):433-439
pubmed: 28665508
J Biol Chem. 1981 Apr 25;256(8):3871-6
pubmed: 6971291
PLoS Biol. 2019 Apr 3;17(4):e3000198
pubmed: 30943210
J Steroid Biochem Mol Biol. 2012 Apr;129(3-5):115-28
pubmed: 22249003
Clin Endocrinol (Oxf). 2000 Dec;53(6):739-47
pubmed: 11155097
Biochemistry. 1983 Jun 7;22(12):2811-20
pubmed: 6307349
Curr Genomics. 2009 Mar;10(1):18-25
pubmed: 19721807
Biol Reprod. 1992 Oct;47(4):644-7
pubmed: 1391352
Eur J Cancer. 1996 Aug;32A(9):1560-5
pubmed: 8911118
Invest New Drugs. 2017 Feb;35(1):87-94
pubmed: 27826831
J Biol Chem. 2014 May 16;289(20):14310-20
pubmed: 24671419
J Biol Chem. 2006 Jul 21;281(29):20404-17
pubmed: 16679316
Biochemistry. 1997 Nov 11;36(45):13816-23
pubmed: 9374858
J Biol Chem. 2018 Jan 12;293(2):541-556
pubmed: 29212707
Nature. 2012 Jan 22;482(7383):116-9
pubmed: 22266943
Drug Metab Dispos. 1984 May-Jun;12(3):358-64
pubmed: 6145564
J Med Chem. 2018 Jun 14;61(11):4946-4960
pubmed: 29792703
J Clin Oncol. 2015 Mar 1;33(7):723-31
pubmed: 25624429
J Steroid Biochem Mol Biol. 2011 May;125(1-2):2-12
pubmed: 21094255
J Clin Endocrinol Metab. 2006 Jul;91(7):2643-9
pubmed: 16608896
Proc Natl Acad Sci U S A. 1996 May 14;93(10):4644-8
pubmed: 8643457
Biochem Biophys Res Commun. 2017 Aug 26;490(3):895-900
pubmed: 28648601
Cancer. 2003 Aug 15;98(4):703-11
pubmed: 12910513
J Biol Chem. 2014 Nov 21;289(47):32952-64
pubmed: 25301938
Arch Biochem Biophys. 2011 Mar 1;507(1):144-53
pubmed: 21055385
J Natl Cancer Inst. 2014 Jan;106(1):djt319
pubmed: 24273215
Ann Oncol. 2016 Jan;27(1):106-13
pubmed: 26504153
J Biol Chem. 2013 Jun 7;288(23):17008-17018
pubmed: 23620596
Cancer Res. 2002 Aug 1;62(15):4499-506
pubmed: 12154061
Biochemistry. 1995 Oct 31;34(43):14104-13
pubmed: 7578007
J Biol Chem. 2016 Aug 12;291(33):17143-64
pubmed: 27339894
J Biol Chem. 1996 May 24;271(21):12445-50
pubmed: 8647850
J Clin Invest. 2017 Jun 1;127(6):2326-2338
pubmed: 28463227
J Med Chem. 1998 Dec 31;41(27):5375-81
pubmed: 9876107
J Pharmacol Exp Ther. 2020 Sep;374(3):438-451
pubmed: 32554434
Biochem J. 1995 Jun 15;308 ( Pt 3):901-8
pubmed: 8948449
Clin Genitourin Cancer. 2020 Aug;18(4):258-267.e1
pubmed: 32327394
World J Mens Health. 2019 Sep;37(3):288-295
pubmed: 30209899
J Biol Chem. 1982 Aug 10;257(15):8935-44
pubmed: 6807985
Bioorg Med Chem. 2011 Nov 1;19(21):6383-99
pubmed: 21978946
Endocr Rev. 2011 Feb;32(1):81-151
pubmed: 21051590
Drug Metab Dispos. 2017 Jun;45(6):635-645
pubmed: 28373265
Biochem Biophys Res Commun. 1979 Oct 12;90(3):925-32
pubmed: 228675
Brain Res Mol Brain Res. 1999 Mar 20;66(1-2):35-41
pubmed: 10095075
Science. 1986 Dec 5;234(4781):1258-61
pubmed: 3535074
Mol Cell Endocrinol. 2017 Feb 5;441:116-123
pubmed: 27471004
Breast Cancer Res Treat. 2010 May;121(1):1-11
pubmed: 19533338
J Med Chem. 1995 Jun 23;38(13):2463-71
pubmed: 7608911
Biochem J. 1998 Jun 1;332 ( Pt 2):293-6
pubmed: 9601054
J Am Chem Soc. 2019 Dec 26;141(51):20079-20088
pubmed: 31741382
J Steroid Biochem Mol Biol. 2014 Sep;143:1-10
pubmed: 24508512
J Am Chem Soc. 2013 Nov 6;135(44):16245-7
pubmed: 24160919
J Biol Chem. 2013 Jul 26;288(30):22080-95
pubmed: 23709268
Biochem Biophys Res Commun. 2016 Aug 19;477(2):202-8
pubmed: 27297105
Bioorg Med Chem Lett. 2014 Jun 1;24(11):2444-7
pubmed: 24775307
Development. 1988 Dec;104(4):689-701
pubmed: 3268410
N Engl J Med. 2011 May 26;364(21):1995-2005
pubmed: 21612468
Mol Endocrinol. 2015 Aug;29(8):1156-69
pubmed: 26083833
Ann Transl Med. 2015 Jun;3(9):121
pubmed: 26207249
Trends Endocrinol Metab. 2004 Nov;15(9):432-8
pubmed: 15519890
Biochemistry. 2016 Aug 9;55(31):4356-65
pubmed: 27426448
J Biol Chem. 1975 Sep 25;250(18):7405-14
pubmed: 1165247
Cell Death Dis. 2012 Jan 12;3:e249
pubmed: 22237206
J Clin Endocrinol Metab. 2012 Feb;97(2):507-16
pubmed: 22170708
Am J Med Genet A. 2004 Jul 30;128A(3):223-31
pubmed: 15216541
Eur J Biochem. 2003 Mar;270(6):1349-55
pubmed: 12631293
J Steroid Biochem Mol Biol. 2015 Jul;151:52-65
pubmed: 25482340
Biochemistry. 2012 Sep 11;51(36):7064-77
pubmed: 22873692
J Clin Oncol. 2007 Jul 1;25(19):2685-90
pubmed: 17548841
J Clin Endocrinol Metab. 2015 Jun;100(6):2283-90
pubmed: 25850025
J Clin Endocrinol Metab. 2012 Mar;97(3):E367-75
pubmed: 22170725
J Am Chem Soc. 2018 Jun 13;140(23):7324-7331
pubmed: 29758981
Clin Chem Lab Med. 2020 Feb 25;58(3):326-339
pubmed: 31714881
J Biol Chem. 2019 Jun 28;294(26):10028-10041
pubmed: 31072872
Biochemistry. 1976 Nov 30;15(24):5399-406
pubmed: 187215
Arch Biochem Biophys. 1971 Mar;143(1):66-79
pubmed: 4397839
J Steroid Biochem Mol Biol. 2010 Apr;119(3-5):112-20
pubmed: 20043997
Front Oncol. 2012 Dec 05;2:186
pubmed: 23227453
J Am Chem Soc. 2019 Apr 3;141(13):5504-5510
pubmed: 30892878
Biochemistry. 2001 Apr 17;40(15):4879-91
pubmed: 11294656
Oncogenesis. 2017 May 22;6(5):e339
pubmed: 28530704
Biochem J. 1982 Mar 1;201(3):569-80
pubmed: 7092812
PLoS Biol. 2019 Feb 14;17(2):e3000002
pubmed: 30763313
Arch Biochem Biophys. 1995 Mar 10;317(2):343-7
pubmed: 7893148
J Biol Chem. 2017 Aug 11;292(32):13168-13185
pubmed: 28684414
J Clin Endocrinol Metab. 1993 Jul;77(1):98-102
pubmed: 8325965
J Physiol. 2011 May 15;589(Pt 10):2585-96
pubmed: 21486789
J Biol Chem. 2013 Jun 14;288(24):17082-90
pubmed: 23632020
J Am Chem Soc. 2014 Oct 22;136(42):15016-25
pubmed: 25252141
FEBS Lett. 2007 May 22;581(11):2076-82
pubmed: 17316621
Cancers (Basel). 2019 Sep 16;11(9):
pubmed: 31527549
Biochemistry. 1974 Apr 9;13(8):1701-10
pubmed: 4151581
J Med Chem. 2005 Apr 21;48(8):2972-84
pubmed: 15828836
J Clin Endocrinol Metab. 2012 Feb;97(2):E257-67
pubmed: 22162478
J Biol Chem. 2004 Jun 25;279(26):27294-301
pubmed: 15100217
Front Oncol. 2019 Aug 28;9:801
pubmed: 31555580
Proc Natl Acad Sci U S A. 2015 Dec 29;112(52):15856-61
pubmed: 26668369
J Biol Chem. 1998 Feb 6;273(6):3158-65
pubmed: 9452426
Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13196-201
pubmed: 14563924
Compr Physiol. 2014 Oct;4(4):1369-81
pubmed: 25428847
J Med Chem. 1995 Oct 13;38(21):4191-7
pubmed: 7473546
Biochemistry. 1994 Apr 12;33(14):4410-8
pubmed: 8155659
Lancet Oncol. 2012 Oct;13(10):983-92
pubmed: 22995653
J Steroid Biochem Mol Biol. 2017 Jan;165(Pt B):312-322
pubmed: 27471148
Science. 1993 Aug 6;261(5122):731-6
pubmed: 8342039
J Mol Biol. 2010 Jul 30;400(5):1078-98
pubmed: 20595043
Endocrinol Metab Clin North Am. 2001 Mar;30(1):101-19, vii
pubmed: 11344930
Endocr J. 1998 Feb;45(1):89-95
pubmed: 9625451
Breast Cancer Res Treat. 2018 Aug;171(1):111-120
pubmed: 29744674
Breast Cancer Res Treat. 2008 Dec;112(3):489-501
pubmed: 18338247
EMBO J. 2011 Jun 24;30(15):3019-27
pubmed: 21701558
J Clin Endocrinol Metab. 1999 Sep;84(9):3382-5
pubmed: 10487714
Anat Embryol (Berl). 1996 Aug;194(2):111-34
pubmed: 8827321
Nat Struct Biol. 1997 Feb;4(2):140-6
pubmed: 9033595
Lancet Oncol. 2015 Mar;16(3):338-48
pubmed: 25701170
Biochemistry. 2018 Feb 6;57(5):764-771
pubmed: 29283561

Auteurs

Sarah D Burris-Hiday (SD)

Department of Medicinal Chemistry, University of Michigan, Ann Arbor, MI, USA. Electronic address: scottee@umich.edu.

Emily E Scott (EE)

Department of Medicinal Chemistry, University of Michigan, Ann Arbor, MI, USA; Department of Pharmacology, University of Michigan, Ann Arbor, MI, USA.

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Classifications MeSH

questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Maladies du sein › Tumeurs du sein › Steroidogenic cytochrome P450 17A1 structure...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Éléments structuraux des protéines › Domaine catalytique › Steroidogenic cytochrome P450 17A1 structure...
questionsmedicales.fr › Maladies endocriniennes › Maladies des surrénales › Hypercorticisme › Syndrome de Cushing › Steroidogenic cytochrome P450 17A1 structure...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu nerveux › Tumeurs neuroectodermiques › Tumeurs neuroépitheliales › Gliome › Astrocytome › Glioblastome › Steroidogenic cytochrome P450 17A1 structure...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Steroidogenic cytochrome P450 17A1 structure...
questionsmedicales.fr › Métabolisme › Hydroxylation › Steroidogenic cytochrome P450 17A1 structure...
questionsmedicales.fr › Maladies urogénitales › Tumeurs de l'appareil urogénital › Tumeurs de l'appareil génital mâle › Tumeurs de la prostate › Steroidogenic cytochrome P450 17A1 structure...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Hémoprotéines › Cytochromes › Cytochrome P-450 enzyme system › Steroid hydroxylases › Steroid 17-alpha-hydroxylase › Steroidogenic cytochrome P450 17A1 structure...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Spécificité du substrat › Steroidogenic cytochrome P450 17A1 structure...