Prenatal developmental toxicity studies on fumes from oxidised asphalt (OA) in the rat.

Animals Female Hydrocarbons / toxicity Inhalation Exposure Lung Male Occupational Exposure Pregnancy Rats Reproduction
Fume OECD 414 Oxidised asphalt Prenatal developmental toxicity Teratogenicity Workplace

Journal

Reproductive toxicology (Elmsford, N.Y.)
ISSN: 1873-1708
Titre abrégé: Reprod Toxicol
Pays: United States
ID NLM: 8803591

Informations de publication

Date de publication:
06 2021
Historique:
received: 08 12 2020
revised: 25 02 2021
accepted: 15 03 2021
pubmed: 31 3 2021
medline: 15 12 2021
entrez: 30 3 2021
Statut: ppublish

Résumé

The prenatal developmental toxicity of the fumes of oxidised asphalt (OA) was tested by nose-only inhalation in the rat. The test material was generated by collecting fumes from the headspace of storage tanks filled with OA. The composition of these fumes was matched to fumes sampled at a workplace where the same OA was applied in a pour-and-roll operation, representing occupational exposure with high concentrations of fumes to not underestimate the possible hazard. In the main study, dams were exposed to 0, 53, 158 and 536 mg/m

Identifiants

DOI: 10.1016/j.reprotox.2021.03.003 PMID: 33781938
pubmed: 33781938
pii: S0890-6238(21)00047-2
doi: 10.1016/j.reprotox.2021.03.003
pii:
doi:

Substances chimiques

Hydrocarbons 0
asphalt 8052-42-4

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

67-79

Informations de copyright

Copyright © 2021. Published by Elsevier Inc.

Auteurs

Peter J Boogaard (PJ)

Shell Health, Shell International bv, PO Box 162, 2501 AN The Hague, The Netherlands; Toxicology Group in CONCAWE, Brussels, Belgium. Electronic address: peter.boogaard@shell.com.

Jochen Buschmann (J)

General and Reproductive Toxicology Consultancy, Haegewiesen 93, 30657 Hannover, Germany; Fraunhofer Institute for Toxicology and Experimental Medicine, Nikolai-Fuchs-Straße 1, 30625 Hannover, Germany. Electronic address: jbuschm333@aol.com.

Rainer Fuhst (R)

Fraunhofer Institute for Toxicology and Experimental Medicine, Nikolai-Fuchs-Straße 1, 30625 Hannover, Germany.

Katharina Blümlein (K)

Fraunhofer Institute for Toxicology and Experimental Medicine, Nikolai-Fuchs-Straße 1, 30625 Hannover, Germany.

Wolfgang Koch (W)

Fraunhofer Institute for Toxicology and Experimental Medicine, Nikolai-Fuchs-Straße 1, 30625 Hannover, Germany. Electronic address: wolfgang.koch@item.fraunhofer.de.

Dirk Schaudien (D)

Fraunhofer Institute for Toxicology and Experimental Medicine, Nikolai-Fuchs-Straße 1, 30625 Hannover, Germany.

Katharina Schwarz (K)

Fraunhofer Institute for Toxicology and Experimental Medicine, Nikolai-Fuchs-Straße 1, 30625 Hannover, Germany.

Christine McAlinden (C)

toXcel International, PO Box 93, Ledbury, Herefordshire HR8 9JE, United Kingdom. Electronic address: christine.mcalinden@toxcel.co.uk.

Lize Deferme (L)

ExxonMobil Petroleum and Chemical bv, Hermeslaan 2, 1831 Machelen, Belgium; Toxicology Group in CONCAWE, Brussels, Belgium. Electronic address: lize.deferme@exxonmobil.com.

Mathieu Vaissiere (M)

Total, 24 cours Michelet, 92800 Puteaux, France; Toxicology Group in CONCAWE, Brussels, Belgium. Electronic address: mathieu.vaissiere@total.com.

Hans B Ketelslegers (HB)

CONCAWE, Vorstlaan 165, B-1160 Brussels, Belgium. Electronic address: hans.ketelslegers@concawe.eu.

Anna Steneholm (A)

Nynas, P.O. Box 10 700, SE-121 29 Stockholm, Sweden; Toxicology Group in CONCAWE, Brussels, Belgium. Electronic address: anna.steneholm@nynas.com.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Prenatal developmental toxicity studies on...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Prenatal developmental toxicity studies on...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Pollution de l'environnement › Exposition environnementale › Exposition par inhalation › Prenatal developmental toxicity studies on...
questionsmedicales.fr › Appareil respiratoire › Poumon › Prenatal developmental toxicity studies on...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Pollution de l'environnement › Exposition environnementale › Exposition professionnelle › Prenatal developmental toxicity studies on...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Prenatal developmental toxicity studies on...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Prenatal developmental toxicity studies on...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Prenatal developmental toxicity studies on...