The development and stem cells of the esophagus.
Enteric nervous system
Esophageal atresia
Esophageal development
Human pluripotent stem cells
Tracheoesophageal separation
Journal
Development (Cambridge, England)
ISSN: 1477-9129
Titre abrégé: Development
Pays: England
ID NLM: 8701744
Informations de publication
Date de publication:
29 03 2021
29 03 2021
Historique:
entrez:
30
3
2021
pubmed:
31
3
2021
medline:
7
9
2021
Statut:
epublish
Résumé
The esophagus is derived from the anterior portion of the foregut endoderm, which also gives rise to the respiratory system. As it develops, the esophageal lining is transformed from a simple columnar epithelium into a stratified squamous cell layer, accompanied by the replacement of unspecified mesenchyme with layers of muscle cells. Studies in animal models have provided significant insights into the roles of various signaling pathways in esophageal development. More recent studies using human pluripotent stem cells (hPSCs) further demonstrate that some of these signaling pathways are conserved in human esophageal development. In addition, a combination of mouse genetics and hPSC differentiation approaches have uncovered new players that control esophageal morphogenesis. In this Review, we summarize these new findings and discuss how the esophagus is established and matures throughout different stages, including its initial specification, respiratory-esophageal separation, epithelial morphogenesis and maintenance. We also discuss esophageal muscular development and enteric nervous system innervation, which are essential for esophageal structure and function.
Identifiants
pubmed: 33782045
pii: 148/6/dev193839
doi: 10.1242/dev.193839
pmc: PMC8034879
pii:
doi:
Substances chimiques
Hedgehog Proteins
0
Transcription Factors
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL152293
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK100342
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL132996
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA013696
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK120650
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK113144
Pays : United States
Informations de copyright
© 2021. Published by The Company of Biologists Ltd.
Déclaration de conflit d'intérêts
Competing interestsThe authors declare no competing or financial interests.
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