An inhibitory hippocampal-thalamic pathway modulates remote memory retrieval.
Journal
Nature neuroscience
ISSN: 1546-1726
Titre abrégé: Nat Neurosci
Pays: United States
ID NLM: 9809671
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
received:
01
10
2018
accepted:
18
02
2021
pubmed:
31
3
2021
medline:
23
6
2021
entrez:
30
3
2021
Statut:
ppublish
Résumé
Memories are supported by distributed hippocampal-thalamic-cortical networks, but the brain regions that contribute to network activity may vary with memory age. This process of reorganization is referred to as systems consolidation, and previous studies have examined the relationship between the activation of different hippocampal, thalamic, and cortical brain regions and memory age at the time of recall. While the activation of some brain regions increases with memory age, other regions become less active. In mice, here we show that the active disengagement of one such brain region, the anterodorsal thalamic nucleus, is necessary for recall at remote time-points and, in addition, which projection(s) mediate such inhibition. Specifically, we identified a sparse inhibitory projection from CA3 to the anterodorsal thalamic nucleus that becomes more active during systems consolidation, such that it is necessary for contextual fear memory retrieval at remote, but not recent, time-points post-learning.
Identifiants
pubmed: 33782621
doi: 10.1038/s41593-021-00819-3
pii: 10.1038/s41593-021-00819-3
pmc: PMC8715645
mid: NIHMS1761639
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
685-693Subventions
Organisme : NIMH NIH HHS
ID : F31 MH120920
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH119421
Pays : United States
Organisme : CIHR
ID : MOP74650
Pays : Canada
Organisme : CIHR
ID : FDN143227
Pays : Canada
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