Startle to neutral, not negative stimuli: A neurophysiological correlate of behavioral inhibition in young children.
anxiety
behavioral inhibition
early childhood
startle response
Journal
Developmental psychobiology
ISSN: 1098-2302
Titre abrégé: Dev Psychobiol
Pays: United States
ID NLM: 0164074
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
revised:
27
01
2021
received:
08
05
2020
accepted:
06
03
2021
pubmed:
31
3
2021
medline:
26
3
2022
entrez:
30
3
2021
Statut:
ppublish
Résumé
A putative biomarker of anxiety risk, the startle response is typically enhanced by negative compared to neutral emotion modulation in adults, but remains understudied in children. To determine the extent to which neutral, negative, and positively valenced emotional conditions modulate startle response in early life, a child-friendly film paradigm was used to vary emotion across these conditions during startle induction in sixty-four 4- to 7-year-old children. Association of emotion-modulated startle with parent-reported anxiety symptom severity and child behavioral inhibition, a risk factor for anxiety problems, were assessed. Analyses revealed no difference in startle magnitude during negative compared to neutral film clips. By contrast, startle during both negative and neutral conditions was greater than startle during the positive condition. Larger startle magnitude during the neutral condition associated with higher levels of child behavioral inhibition (BI). These results are consistent with possible immaturity of startle response in young children, and suggest that startle amplitude in more emotionally ambiguous, neutral conditions could serve as an early biomarker for anxiety risk.
Identifiants
pubmed: 33782955
doi: 10.1002/dev.22120
pmc: PMC8355024
mid: NIHMS1684417
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1322-1329Subventions
Organisme : NIMH NIH HHS
ID : R03 MH102648
Pays : United States
Organisme : NIMH NIH HHS
ID : R33 MH121641
Pays : United States
Informations de copyright
© 2021 Wiley Periodicals LLC.
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