Paternal multigenerational exposure to an obesogenic diet drives epigenetic predisposition to metabolic diseases in mice.
developmental biology
epigenetic
inheritance
mouse
obesity
sperm
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
30 03 2021
30 03 2021
Historique:
received:
03
08
2020
accepted:
28
03
2021
pubmed:
31
3
2021
medline:
14
9
2021
entrez:
30
3
2021
Statut:
epublish
Résumé
Obesity is a growing societal scourge. Recent studies have uncovered that paternal excessive weight induced by an unbalanced diet affects the metabolic health of offspring. These reports mainly employed single-generation male exposure. However, the consequences of multigenerational unbalanced diet feeding on the metabolic health of progeny remain largely unknown. Here, we show that maintaining paternal Western diet feeding for five consecutive generations in mice induces an enhancement in fat mass and related metabolic diseases over generations. Strikingly, chow-diet-fed progenies from these multigenerational Western-diet-fed males develop a 'healthy' overweight phenotype characterized by normal glucose metabolism and without fatty liver that persists for four subsequent generations. Mechanistically, sperm RNA microinjection experiments into zygotes suggest that sperm RNAs are sufficient for establishment but not for long-term maintenance of epigenetic inheritance of metabolic pathologies. Progressive and permanent metabolic deregulation induced by successive paternal Western-diet-fed generations may contribute to the worldwide epidemic of metabolic diseases.
Identifiants
pubmed: 33783350
doi: 10.7554/eLife.61736
pii: 61736
pmc: PMC8051948
doi:
pii:
Banques de données
GEO
['GSE148972', 'GSE138989']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Agence Nationale de la Recherche
ID : NR-12-ADAPT-0022
Organisme : Fonds Francais pour l'Alimentation et la Sante
ID : 15D52
Informations de copyright
© 2021, Raad et al.
Déclaration de conflit d'intérêts
GR, FS, LM, MD, JG, VC, DP, EA, MT, VG No competing interests declared
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