Public attitudes towards the genetic testing in Georgia.
Journal
Journal of community genetics
ISSN: 1868-310X
Titre abrégé: J Community Genet
Pays: Germany
ID NLM: 101551501
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
received:
21
04
2020
accepted:
21
03
2021
pubmed:
31
3
2021
medline:
31
3
2021
entrez:
30
3
2021
Statut:
ppublish
Résumé
The aim of this study is to assess attitudes towards genetic testing in Georgian public. We used a Likert-scale written questionnaire. The survey was completed by 480 respondents. A majority of respondents (75.3%) curious about predictive genetic testing and 40.6% of participants preferred to be tested only for disorders that are treatable or preventable. Approximately 65% of the participants would like to test their newborn children for late-onset disorders and undergo preconception carrier screening (73%). In addition, the majority (59%) of our respondents were not worried that genetic testing would further stigmatize people with disabilities. These results indicate that the respondents surveyed in our study may have placed particularly high importance on the availability of genetic testing and greatly valued access to genomic information.
Identifiants
pubmed: 33783754
doi: 10.1007/s12687-021-00522-7
pii: 10.1007/s12687-021-00522-7
pmc: PMC8241973
doi:
Types de publication
Journal Article
Langues
eng
Pagination
407-414Références
Abzianidze E (2019) Genomic medicine education initiatives in Georgia: key messages and core ideas. International Journal Human Genome and Health 2(1):3–6
Becker F, van El CG, Ibarreta D, Zika E, Hogarth S, Borry P et al (2011) Genetic testing and common disorders in a public health framework: how to assess relevance and possibilities. European Journal of Human Genetics Suppl 1:S6–S44
doi: 10.1038/ejhg.2010.249
Botoseneanu A, Alexander JA, Banaszak-Holl J (2011) To test or not to test? The role of attitudes, knowledge, and religious involvement among U.S. adults on intent-to-obtain adult genetic testing. Health Educ Behav 6:617–628
doi: 10.1177/1090198110389711
Cherkas LF, Harris JM, Levinson E, Spector TD, Prainsack B (2010) A survey of UK public interest in internet-based personal genome testing. PLoS One 10:e13473
doi: 10.1371/journal.pone.0013473
Chokoshvili D, Belmans C, Poncelet R, Sanders S, Vaes D, Vears D, Janssens S, Huys I, Borry P (2017) Public views on genetics and genetic testing: a survey of the general public in Belgium. Genetic Testing and Molecular Biomarkers 21:195–201
doi: 10.1089/gtmb.2016.0418
Chokoshvili D, Vears D, Borry P (2018) Expanded carrier screening for monogenic disorders: where are we now? Prenat Diagn 38(1):59–66
doi: 10.1002/pd.5109
Condit CM (2010) Public attitudes and beliefs about genetics. Annu Rev Genomics Hum Genet 11:339–359
doi: 10.1146/annurev-genom-082509-141740
Douma KFL, Smets EMA, Allain DC (2016) Non-genetic health professionals’ attitude towards, knowledge of and skills in discussing and ordering genetic testing for hereditary cancer. Familial Cancer 15:341–350
doi: 10.1007/s10689-015-9852-6
Etchegary H, Green J, Dicks E, Pullman D, Street C, Parfrey P (2013) Consulting the community: public expectations and attitudes about genetics research. Eur J Hum Genet 12:1338–1343
doi: 10.1038/ejhg.2013.64
Eum H, Lee M, Yoon J, Cho J, Lee ES, Choi KS, Lee S, Jung SY, Lim MC, Kong SY, Chang YJ (2018) Differences in attitudes toward genetic testing among the public, patients, and health-care professionals in Korea. Eur J Hum Genet 26(10):1432–1440
doi: 10.1038/s41431-018-0191-6
Gamkrelidze A, Kereselidze M, Gambashidze K, Kandelaki L, Kazanjan K, Shakhnazarova M, et al. Health Care Statistical yearbook, Georgia: NCDC; 2017. http://ncdc.ge/Handlers/GetFileashx?ID=114b7ef6-0fa1-424a-9c01-6af08ffa63cc ; Accessed Feb 07, 2021
Geelen E, Horstman K, Marcelis CL, Doevendans PA, Van Hoyweghen I (2012) Unravelling fears of genetic discrimination: an exploratory study of Dutch HCM families in an era of genetic non-discrimination acts. Eur J Hum Genet 20(10):1018–1023. https://doi.org/10.1038/ejhg.2012.53
doi: 10.1038/ejhg.2012.53
pubmed: 22453290
pmcid: 3449067
Ginsburg GS, Phillips KA (2018) Precision medicine: from science to value. Health Aff 37(5):694–701
doi: 10.1377/hlthaff.2017.1624
Haga SB, Barry WT, Mills R, Ginsburg GS, Svetkey L, Sullivan J, Willard HF (2013) Public knowledge of and attitudes toward genetics and genetic testing. Genetic Testing and Molecular Biomarkers 17(4):327–335
doi: 10.1089/gtmb.2012.0350
Henneman L, Vermeulen E, van El CG, Claassen L, Timmermans DR, Cornel MC (2013) Public attitudes towards genetic testing revisited: comparing opinions between 2002 and 2010. Eur J Hum Genet 8:793–799
doi: 10.1038/ejhg.2012.271
Joly Y, Braker M, Le Huynh M (2010) Genetic discrimination in private insurance: global perspectives. New Genet Soc 29:351–368
doi: 10.1080/14636778.2010.528189
Kitzman JO, Snyder MW, Ventura M, Lewis AP, Qiu R, Simmons LVE et al (2012) Noninvasive whole-genome sequencing of a human fetus. Sci Transl Med 4(137):137–176
doi: 10.1126/scitranslmed.3004323
Leader AE, Mohanty S, Selvan P, Lum R, Giri VN (2018) Exploring Asian Indian and Pakistani views about cancer and participation in cancer genetics research: toward the development of a community genetics intervention. Journal of Community Genetics 9:27–35
doi: 10.1007/s12687-017-0312-x
Makeeva OA, Markova VV, Roses AD, Puzyrev VP (2010) An epidemiologic-based survey of public attitudes towards predictive genetic testing in Russia. Personalized Medicine 7(3):291–300
doi: 10.2217/pme.10.23
Manjavidze T, Rylander C, Skjeldestad FE, Kazakhashvili N, Anda EE (2019) Incidence and causes of perinatal mortality in Georgia. Journal of Epidemiology and Global Health 9(3):163–168
pubmed: 31529933
pmcid: 7310824
Oliveri S, Masiero M, Arnaboldi P, Cutica I, Fioretti C, Pravettoni G (2016) Health Orientation, Knowledge, and Attitudes toward Genetic Testing and Personalized Genomic Services: Preliminary Data from an Italian Sample. Biomed Res Int 2016:6824581
Phillips KA, Trosman JR, Kelley RK, Pletcher MJ, Douglas MP, Weldon CB (2014) Genomic sequencing: assessing the health care system, policy, and big-data implications. Health Aff 33(7):1246–1253
doi: 10.1377/hlthaff.2014.0020
Phillips KA, Deverka PA, Hooker GW, Douglas MP (2018) Genetic test availability and spending: Where are we now? Where are we going? Health Aff (Millwood) 37(5):710–716
doi: 10.1377/hlthaff.2017.1427
Pritchard DE, Moeckel F, Villa MS, Housman LT, McCarty CA, McLeod HL (2017) Strategies for integrating personalized medicine into healthcare practice. Personalized Medicine 14(2):141–152
doi: 10.2217/pme-2016-0064
Prokop JW, May T, Strong K, Bilinovich SM, Bupp C, Rajasekaran S, Worthey EA, Lazar J (2018) Genome sequencing in the clinic: the past, present, and future of genomic medicine. Physiol Genomics 50:563–579
doi: 10.1152/physiolgenomics.00046.2018
Saunders CJ, Miller NA, Soden SE, Dinwiddie DL, Noll A, Alnadi NA, Andraws N, Patterson ML, Krivohlavek LA, Fellis J, Humphray S, Saffrey P, Kingsbury Z, Weir JC, Betley J, Grocock RJ, Margulies EH, Farrow EG, Artman M, Safina NP, Petrikin JE, Hall KP, Kingsmore SF (2012) Rapid whole-genome sequencing for genetic disease diagnosis in neonatal intensive care units. Sci Transl Med 4(154):154ra135. https://doi.org/10.1126/scitranslmed.3004041
doi: 10.1126/scitranslmed.3004041
pubmed: 23035047
pmcid: 4283791
Shatirishvili A, Dvalishvili N (2015) Preface. In: General Genetics. Ilia State University Press, Tbilisi, Georgia, pp 1–2
Shen J (2016) Precision assessment of public attitudes toward genetic testing. Am J Med Genet A:1–4
Topol EJ (2014) Individualized medicine from prewomb to tomb. Cell 157(1):241–253
doi: 10.1016/j.cell.2014.02.012
UNFPA Country Programme Evaluation: Georgia. www.unfpa.org/sites/default/files/board-documents/Georgia_-_CPE_-_Country_Programme_Evaluation_Report_2019.pdf ()
Vermeulen E, Henneman L, van El CG, Cornel MC (2014) Public attitudes towards preventive genomics and personal interest in genetic testing to prevent disease: a survey study. Eur J Pub Health 5:768–775
doi: 10.1093/eurpub/ckt143
World Health Organization. European health for all database (HFA-DB) (2017) http://www.euro.who.int/en/data-and-evidence/databases/european-health-for-all-family-of-databases-hfa-dbn (Accessed Feb 07, 2021)
Yang JH, Kim SY (2017) Legal and regulatory issues in genetic information discrimination - focusing on overseas regulatory trends and domestic implications. The Korea Society of Law and Medicine 18(1):237–264