Group phenotypic composition in cancer.
cancer biology
ecology
evolutionary biology
medicine
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
30 03 2021
30 03 2021
Historique:
received:
02
10
2020
accepted:
09
03
2021
entrez:
30
3
2021
pubmed:
31
3
2021
medline:
4
9
2021
Statut:
epublish
Résumé
Although individual cancer cells are generally considered the Darwinian units of selection in malignant populations, they frequently act as members of groups where fitness of the group cannot be reduced to the average fitness of individual group members. A growing body of studies reveals limitations of reductionist approaches to explaining biological and clinical observations. For example, induction of angiogenesis, inhibition of the immune system, and niche engineering through environmental acidification and/or remodeling of extracellular matrix cannot be achieved by single tumor cells and require collective actions of groups of cells. Success or failure of such group activities depends on the phenotypic makeup of the individual group members. Conversely, these group activities affect the fitness of individual members of the group, ultimately affecting the composition of the group. This phenomenon, where phenotypic makeup of individual group members impacts the fitness of both members and groups, has been captured in the term 'group phenotypic composition' (GPC). We provide examples where considerations of GPC could help in understanding the evolution and clinical progression of cancers and argue that use of the GPC framework can facilitate new insights into cancer biology and assist with the development of new therapeutic strategies.
Identifiants
pubmed: 33784238
doi: 10.7554/eLife.63518
pii: 63518
pmc: PMC8009660
doi:
pii:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIA NIH HHS
ID : R01 AG067584
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG066544
Pays : United States
Organisme : ANR
ID : ANR-18-CE35-0009
Organisme : Australian Research Council
ID : LP170101105
Organisme : MAVA Foundation
ID : 2020-2023
Organisme : Deakin University
ID : SEBE_RGS_2019
Informations de copyright
© 2021, Capp et al.
Déclaration de conflit d'intérêts
JC, JD, AN, AD, JB, PP, CA, RH, BR, BU, AM, RG, FT No competing interests declared
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