Thyroid function analysis in COVID-19: A retrospective study from a single center.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2021
2021
Historique:
received:
09
01
2021
accepted:
17
03
2021
entrez:
30
3
2021
pubmed:
31
3
2021
medline:
10
4
2021
Statut:
epublish
Résumé
Coronavirus disease 2019 (COVID-19) is an on-going epidemic with a multitude of long-ranging effects on the physiological balance of the human body. It can cause several effects on thyroid functions as well. We aimed to assess the lasting sequelae of COVID-19 on thyroid hormone and the clinical course of the disease as a result. Out of 76 patients, 48 patients of COVID-19 positive and 28 patients of COVID-19 negative polymerase chain reaction (PCR) were assessed for thyroid functions, IL-6, and Procalcitonin between moderate, severe, and critical pneumonia on HRCT. Seventy-five percent of patients with COVID-19 had thyroid abnormalities and higher IL-6 levels (76.10 ± 82.35 vs. 6.99 ± 3.99, 95% CI 52.18-100.01, P-value <0.01). Logistic regression analysis suggested TT3 (P-value 0.01), IL-6 (P-value <0.01), and Procalcitonin (P-value 0.03) as independent risk factors for COVID-19. ROC curve demonstrated IL-6 as the most sensitive marker (P-value <0.01), and TT3, and Procalcitonin as the predictor for COVID-19 disease. This pilot study from Pakistan demonstrates that changes in serum TSH and TT3 levels may be important manifestations of the courses of COVID-19 pneumonia.
Sections du résumé
BACKGROUND AND OBJECTIVE
Coronavirus disease 2019 (COVID-19) is an on-going epidemic with a multitude of long-ranging effects on the physiological balance of the human body. It can cause several effects on thyroid functions as well. We aimed to assess the lasting sequelae of COVID-19 on thyroid hormone and the clinical course of the disease as a result.
METHODS
Out of 76 patients, 48 patients of COVID-19 positive and 28 patients of COVID-19 negative polymerase chain reaction (PCR) were assessed for thyroid functions, IL-6, and Procalcitonin between moderate, severe, and critical pneumonia on HRCT.
RESULTS
Seventy-five percent of patients with COVID-19 had thyroid abnormalities and higher IL-6 levels (76.10 ± 82.35 vs. 6.99 ± 3.99, 95% CI 52.18-100.01, P-value <0.01). Logistic regression analysis suggested TT3 (P-value 0.01), IL-6 (P-value <0.01), and Procalcitonin (P-value 0.03) as independent risk factors for COVID-19. ROC curve demonstrated IL-6 as the most sensitive marker (P-value <0.01), and TT3, and Procalcitonin as the predictor for COVID-19 disease.
CONCLUSION
This pilot study from Pakistan demonstrates that changes in serum TSH and TT3 levels may be important manifestations of the courses of COVID-19 pneumonia.
Identifiants
pubmed: 33784355
doi: 10.1371/journal.pone.0249421
pii: PONE-D-21-00830
pmc: PMC8009384
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0249421Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Asia Pac J Public Health. 2020 May;32(4):154-156
pubmed: 32429679
Indian J Endocrinol Metab. 2011 Jul;15(Suppl 2):S78-81
pubmed: 21966658
J Endocrinol Invest. 2020 Aug;43(8):1169-1170
pubmed: 32488724
Front Endocrinol (Lausanne). 2020 Oct 07;11:566439
pubmed: 33117282
Endocrine. 2020 Jun;68(3):471-474
pubmed: 32507963
Compr Physiol. 2016 Mar 15;6(2):1071-80
pubmed: 27065175
Endocr Pract. 2021 Feb;27(2):101-109
pubmed: 33551316
Circulation. 2020 May 19;141(20):1648-1655
pubmed: 32200663
J Pak Med Assoc. 2020 May;70(Suppl 3)(5):S131-S135
pubmed: 32515393
Eur J Endocrinol. 2020 Oct;183(4):381-387
pubmed: 32698147
Thyroid. 2021 Jan;31(1):8-11
pubmed: 32600165
J Clin Endocrinol Metab. 2020 Oct 1;105(10):
pubmed: 32780854
Nat Rev Endocrinol. 2018 May;14(5):301-316
pubmed: 29569622
Clin Endocrinol (Oxf). 2005 Aug;63(2):197-202
pubmed: 16060914
Pak J Med Sci. 2020 May;36(COVID19-S4):S79-S84
pubmed: 32582319
Rev Endocr Metab Disord. 2020 Nov 25;:
pubmed: 33241508
J Clin Endocrinol Metab. 2020 Jul 1;105(7):
pubmed: 32436948
Asian Pac J Allergy Immunol. 2020 Mar;38(1):1-9
pubmed: 32105090