Auger electron therapy of glioblastoma using [
Auger electrons
Chemotherapy
Glioblastoma
Radionuclide therapy
[(125)I]I-UdR
Journal
Nuclear medicine and biology
ISSN: 1872-9614
Titre abrégé: Nucl Med Biol
Pays: United States
ID NLM: 9304420
Informations de publication
Date de publication:
Historique:
received:
13
11
2020
revised:
15
02
2021
accepted:
07
03
2021
pubmed:
31
3
2021
medline:
17
12
2021
entrez:
30
3
2021
Statut:
ppublish
Résumé
Treatment of glioblastomas (GBM) using the Auger electron emitting compound [ A patient-derived GBM cancer stem cell (CSC)-enriched cell line, grown as neurospheres, was employed to evaluate DNA-incorporation of [ The highest general increase in [ Overall, our study revealed a higher incorporation and therapeutic effect of [ Auger electron therapy in combination with thymidylate synthase inhibition and concomitant chemotherapy has the potential to become a future therapeutic treatment option for patients with glioblastoma.
Identifiants
pubmed: 33784592
pii: S0969-8051(21)00040-8
doi: 10.1016/j.nucmedbio.2021.03.001
pii:
doi:
Substances chimiques
Iodine Radioisotopes
0
Iodine-125
GVO776611R
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
35-40Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.