Impact of Baseline and On-Treatment Glycemia on Everolimus-Exemestane Efficacy in Patients with Hormone Receptor-Positive Advanced Breast Cancer (EVERMET).


Journal

Clinical cancer research : an official journal of the American Association for Cancer Research
ISSN: 1557-3265
Titre abrégé: Clin Cancer Res
Pays: United States
ID NLM: 9502500

Informations de publication

Date de publication:
15 06 2021
Historique:
received: 23 12 2020
revised: 24 02 2021
accepted: 26 03 2021
pubmed: 1 4 2021
medline: 8 4 2022
entrez: 31 3 2021
Statut: ppublish

Résumé

The mTOR complex C1 (mTORC1) inhibitor everolimus in combination with the aromatase inhibitor exemestane is an effective treatment for patients with hormone receptor-positive (HR We conducted a multicenter, retrospective, Italian study to investigate the impact of baseline and on-treatment (i.e., during first 3 months of therapy) blood glucose levels on progression-free survival (PFS) in patients with HR We evaluated 809 patients with HR The impact of on-treatment glycemia on the efficacy of everolimus-exemestane therapy in patients with HR

Identifiants

pubmed: 33785482
pii: 1078-0432.CCR-20-4928
doi: 10.1158/1078-0432.CCR-20-4928
doi:

Substances chimiques

Androstadienes 0
Blood Glucose 0
Receptors, Estrogen 0
Everolimus 9HW64Q8G6G
Receptor, ErbB-2 EC 2.7.10.1
exemestane NY22HMQ4BX

Types de publication

Journal Article Multicenter Study Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

3443-3455

Informations de copyright

©2021 American Association for Cancer Research.

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Auteurs

Claudio Vernieri (C)

Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. claudio.vernieri@istitutotumori.mi.it.
IFOM, the FIRC Institute of Molecular Oncology, Milan, Italy.

Federico Nichetti (F)

Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

Luca Lalli (L)

Unit of Clinical Epidemiology and Trial Organization, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

Luca Moscetti (L)

Division of Medical Oncology, Department of Oncology and Hematology, University Hospital of Modena, Modena, Italy.

Carlo Alberto Giorgi (CA)

Medical Oncology 2, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy.

Gaia Griguolo (G)

Medical Oncology 2, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy.
Department of Surgery, Oncology and Gastroenterology, University of Padova, Padua, Italy.

Antonio Marra (A)

Division of Early Drug Development for Innovative Therapies, IEO, European Institute of Oncology IRCCS, Milan, Italy.

Giovanni Randon (G)

Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

Carmen G Rea (CG)

Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

Francesca Ligorio (F)

Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

Simone Scagnoli (S)

Department of Medico-Surgical Sciences and Translational Medicine, "Sapienza" University of Rome, Rome, Italy.

Claudia De Angelis (C)

UO Oncologia Medica 2, Ospedale S. Chiara, Dipartimento di Oncologia, Dei Trapianti e Delle Nuove Tecnologie, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy.

Chiara Molinelli (C)

IRCCS Ospedale Policlinico San Martino, U.O.S.D. Breast Unit, Genova, Italy.

Agnese Fabbri (A)

Medical Oncology Unit, Belcolle Hospital, Viterbo, Italy.

Emanuela Ferraro (E)

Division of Early Drug Development for Innovative Therapies, IEO, European Institute of Oncology IRCCS, Milan, Italy.

Dario Trapani (D)

Division of Early Drug Development for Innovative Therapies, IEO, European Institute of Oncology IRCCS, Milan, Italy.

Andrea Milani (A)

Multidisciplinary Oncology Outpatient Clinic, Candiolo Cancer Institute, FPO-IRCCS, Turin, Italy.

Elisa Agostinetto (E)

Medical Oncology and Hematology Unit, Humanitas Clinical and Research Center - IRCCS, Rozzano, Milan, Italy.

Ottavia Bernocchi (O)

Department of Medical, Surgery and Health Sciences, University of Trieste, Trieste, Italy.

Giovanna Catania (G)

Division of Medical Oncology, IRCCS Regina Elena National Cancer Institute, Rome, Italy.

Amelia Vantaggiato (A)

Medical Oncology & Breast Unit, "Vito Fazzi" Hospital, Lecce, Italy.

Michela Palleschi (M)

Department of Medical Oncology, IRCCS Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" - IRST, Meldola, Italy.

Anna Moretti (A)

Department of Oncology, ASST Fatebenefratelli Sacco - PO Fatebenefratelli, Milan, Italy.

Debora Basile (D)

Department of Medical Oncology, IRCCS Centro di Riferimento Oncologico di Aviano (CRO), Aviano, Italy.

Marika Cinausero (M)

Department of Oncology, ASUFC University Hospital of Udine, Udine, Italy.

Arta Ajazi (A)

IFOM, the FIRC Institute of Molecular Oncology, Milan, Italy.

Lorenzo Castagnoli (L)

Molecular Targeting Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

Salvatore Lo Vullo (S)

Unit of Clinical Epidemiology and Trial Organization, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

Lorenzo Gerratana (L)

Department of Medical Oncology, IRCCS Centro di Riferimento Oncologico di Aviano (CRO), Aviano, Italy.
Department of Medicine, University of Udine, Udine, Italy.

Fabio Puglisi (F)

Department of Medical Oncology, IRCCS Centro di Riferimento Oncologico di Aviano (CRO), Aviano, Italy.
Department of Medicine, University of Udine, Udine, Italy.

Nicla La Verde (N)

Department of Oncology, ASST Fatebenefratelli Sacco - PO Luigi Sacco, Milan, Italy.

Grazia Arpino (G)

Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.

Andrea Rocca (A)

Department of Medical Oncology, IRCCS Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" - IRST, Meldola, Italy.

Mariangela Ciccarese (M)

Medical Oncology & Breast Unit, "Vito Fazzi" Hospital, Lecce, Italy.

Rebecca Pedersini (R)

Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, Medical Oncology, University of Brescia at ASST Spedali Civili, Brescia, Italy.

Alessandra Fabi (A)

Division of Medical Oncology, IRCCS Regina Elena National Cancer Institute, Rome, Italy.

Daniele Generali (D)

Department of Medical, Surgery and Health Sciences, University of Trieste, Trieste, Italy.
Breast Cancer Unit & Translational Research Unit, ASST Cremona, Cremona, Italy.

Agnese Losurdo (A)

Medical Oncology and Hematology Unit, Humanitas Clinical and Research Center - IRCCS, Rozzano, Milan, Italy.

Filippo Montemurro (F)

Multidisciplinary Oncology Outpatient Clinic, Candiolo Cancer Institute, FPO-IRCCS, Turin, Italy.

Giuseppe Curigliano (G)

Division of Early Drug Development for Innovative Therapies, IEO, European Institute of Oncology IRCCS, Milan, Italy.
Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.

Lucia Del Mastro (L)

IRCCS Ospedale Policlinico San Martino, U.O.S.D. Breast Unit, Genova, Italy.
Dipartimento di Medicina Interna e Specialità Mediche (DiMI), School of Medicine, University of Genova, Genova, Italy.

Andrea Michelotti (A)

UO Oncologia Medica 2, Ospedale S. Chiara, Dipartimento di Oncologia, Dei Trapianti e Delle Nuove Tecnologie, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy.

Enrico Cortesi (E)

Department of Medico-Surgical Sciences and Translational Medicine, "Sapienza" University of Rome, Rome, Italy.

Valentina Guarneri (V)

Medical Oncology 2, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy.
Department of Surgery, Oncology and Gastroenterology, University of Padova, Padua, Italy.

Giancarlo Pruneri (G)

Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.
Department of Diagnostic Pathology and Laboratory Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

Luigi Mariani (L)

Unit of Clinical Epidemiology and Trial Organization, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

Filippo de Braud (F)

Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.

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