Global Transcriptional Regulators Fine-Tune the Translational and Metabolic Efficiency for Optimal Growth of Escherichia coli.

anaerobic fermentation exponential growth global transcriptional regulators intracellular metabolites metabolic and translational efficiency proteome allocation

Journal

mSystems
ISSN: 2379-5077
Titre abrégé: mSystems
Pays: United States
ID NLM: 101680636

Informations de publication

Date de publication:
30 Mar 2021
Historique:
entrez: 31 3 2021
pubmed: 1 4 2021
medline: 1 4 2021
Statut: epublish

Résumé

Global transcriptional regulators coordinate complex genetic interactions that bestow better adaptability for an organism against external and internal perturbations. These transcriptional regulators are known to control an enormous array of genes with diverse functionalities. However, regulator-driven molecular mechanisms that underpin precisely tuned translational and metabolic processes conducive for rapid exponential growth remain obscure. Here, we comprehensively reveal the fundamental role of global transcriptional regulators FNR, ArcA, and IHF in sustaining translational and metabolic efficiency under glucose fermentative conditions in

Identifiants

pubmed: 33785570
pii: 6/2/e00001-21
doi: 10.1128/mSystems.00001-21
pmc: PMC8546960
pii:
doi:

Types de publication

Journal Article

Langues

eng

Informations de copyright

Copyright © 2021 Iyer et al.

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Auteurs

Mahesh S Iyer (MS)

Department of Chemical Engineering, Indian Institute of Technology Bombay, Mumbai, India.

Ankita Pal (A)

Department of Chemical Engineering, Indian Institute of Technology Bombay, Mumbai, India.

Sumana Srinivasan (S)

Department of Chemical Engineering, Indian Institute of Technology Bombay, Mumbai, India.

Pramod R Somvanshi (PR)

Department of Chemical Engineering, Indian Institute of Technology Bombay, Mumbai, India.

K V Venkatesh (KV)

Department of Chemical Engineering, Indian Institute of Technology Bombay, Mumbai, India venks@iitb.ac.in.

Classifications MeSH