Fasting alters the gut microbiome reducing blood pressure and body weight in metabolic syndrome patients.
Aged
Akkermansia
/ physiology
Blood Pressure
/ physiology
Body Mass Index
Body Weight
/ physiology
Desulfovibrionaceae
/ physiology
Diet
Fasting
/ physiology
Feces
/ microbiology
Female
Gastrointestinal Microbiome
/ physiology
Humans
Hypertension
/ complications
Male
Metabolic Syndrome
/ complications
Middle Aged
Ruminococcus
/ physiology
T-Lymphocyte Subsets
/ immunology
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
30 03 2021
30 03 2021
Historique:
received:
13
02
2020
accepted:
26
02
2021
entrez:
31
3
2021
pubmed:
1
4
2021
medline:
20
4
2021
Statut:
epublish
Résumé
Periods of fasting and refeeding may reduce cardiometabolic risk elevated by Western diet. Here we show in the substudy of NCT02099968, investigating the clinical parameters, the immunome and gut microbiome exploratory endpoints, that in hypertensive metabolic syndrome patients, a 5-day fast followed by a modified Dietary Approach to Stop Hypertension diet reduces systolic blood pressure, need for antihypertensive medications, body-mass index at three months post intervention compared to a modified Dietary Approach to Stop Hypertension diet alone. Fasting alters the gut microbiome, impacting bacterial taxa and gene modules associated with short-chain fatty acid production. Cross-system analyses reveal a positive correlation of circulating mucosa-associated invariant T cells, non-classical monocytes and CD4
Identifiants
pubmed: 33785752
doi: 10.1038/s41467-021-22097-0
pii: 10.1038/s41467-021-22097-0
pmc: PMC8010079
doi:
Banques de données
ClinicalTrials.gov
['NCT02099968']
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1970Références
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