Incidence and short-term outcomes of Kawasaki disease.

Adolescent Child Child, Preschool Female Humans Incidence Male Mucocutaneous Lymph Node Syndrome / epidemiology Ontario / epidemiology Retrospective Studies Risk Factors Treatment Outcome

Journal

Pediatric research
ISSN: 1530-0447
Titre abrégé: Pediatr Res
Pays: United States
ID NLM: 0100714

Informations de publication

Date de publication:
09 2021
Historique:
received: 24 10 2020
accepted: 07 03 2021
revised: 04 03 2021
pubmed: 1 4 2021
medline: 18 3 2022
entrez: 31 3 2021
Statut: ppublish

Résumé

Kawasaki disease (KD) is a childhood vasculitis with conflicting reported North American trends in incidence and patient characteristics. (1) determine KD incidence between 1995 and 2017; (2) compare patient characteristics by era and age group; (3) determine complication and cardiovascular follow-up rates. We used population-based health administrative data to identify children (0-18 yr) hospitalized with KD in Ontario, Canada between 1995 and 2017. We excluded children with prior KD diagnosis or incomplete records. We determined the annualized incidence and follow-up trends. KD was diagnosed in 4,346 children between 1995 and 2017. Annual KD incidence was 22.0 (<5 yr), 6.1 (5-9 yr), and 0.6 (10-18 yr) per 100,000 children. KD incidence increased significantly for all age groups, including from 18.4 to 25.0 cases per 100,000 children <5 yr. Ninety-day mortality occurred in ≤5 children (≤0.1%). Coronary artery aneurysm (CAA) occurred in 106 children (2.4%, 95% confidence interval 2.0-2.9) during admission and 151 (3.5%, 95% confidence interval 3.0-4.1) during 11-year median follow-up. Children 10-18 yr had longer hospitalizations (4.3 vs. 3.5 days, p = 0.003) and more CAA (7.4% vs. 3.4%, p = 0.007). By 1-year post-diagnosis, 3970 (91.3%) and 2576 (59.3%) children had echocardiography and cardiology follow-up, respectively. KD incidence is increasing in Ontario, with greater healthcare utilization from hospitalizations and subsequent follow-up. 4346 children were hospitalized for Kawasaki disease over 22 years in Ontario, and Kawasaki disease incidence increased significantly for all age groups, males and females. Older children (10-18 years) had longer hospital length of stay, more PICU admissions and more frequent coronary artery aneurysms. Nearly all children with Kawasaki disease had follow-up echocardiography within 1 year.

Identifiants

DOI: 10.1038/s41390-021-01496-5 PMID: 33785879
pubmed: 33785879
doi: 10.1038/s41390-021-01496-5
pii: 10.1038/s41390-021-01496-5
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

670-677

Subventions

Organisme : CIHR
Pays : Canada

Informations de copyright

© 2021. The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc.

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Auteurs

Cal Robinson (C)

Department of Pediatrics, McMaster University, Hamilton, ON, Canada.

Rahul Chanchlani (R)

Division of Pediatric Nephrology, Department of Pediatrics, McMaster University, Hamilton, ON, Canada.
Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada.
ICES McMaster, Hamilton, ON, Canada.

Anastasia Gayowsky (A)

ICES McMaster, Hamilton, ON, Canada.

Sandeep Brar (S)

Department of Epidemiology & Biostatistics, University of California, San Francisco, CA, USA.

Elizabeth Darling (E)

McMaster Midwifery Research Centre, McMaster University, Hamilton, ON, Canada.

Catherine Demers (C)

Department of Medicine, Division of Cardiology, McMaster University, Hamilton, ON, Canada.

Jennifer Klowak (J)

Department of Pediatrics, McMaster University, Hamilton, ON, Canada.

Braden Knight (B)

ICES Ottawa, Ottawa, ON, Canada.
Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada.

Ellen Kuenzig (E)

ICES Ottawa, Ottawa, ON, Canada.
Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada.

Tapas Mondal (T)

Division of Pediatric Cardiology, Department of Pediatrics, McMaster University, Hamilton, ON, Canada.

Rulan Parekh (R)

Division of Pediatric Nephrology, Department of Pediatrics, University of Toronto, Toronto, ON, Canada.

Hsien Seow (H)

Department of Oncology, McMaster University, Hamilton, ON, Canada.

Carolina Jimenez-Rivera (C)

Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada.
Division of Gastroenterology, Hepatology and Nutrition, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada.
Department of Pediatrics, University of Ottawa, Ottawa, ON, Canada.

Richard Webster (R)

Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada.

Stephen Fung (S)

Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada.

Eric I Benchimol (EI)

ICES Ottawa, Ottawa, ON, Canada.
Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada.
Division of Gastroenterology, Hepatology and Nutrition, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada.
Department of Pediatrics, University of Ottawa, Ottawa, ON, Canada.
School of Epidemiology and Public Health, University of Ottawa, Ottawa, ON, Canada.

Michelle Batthish (M)

Division of Pediatric Rheumatology, Department of Pediatrics, McMaster University, Hamilton, ON, Canada. batthim@mcmaster.ca.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adolescent › Incidence and short-term outcomes of Kawasaki disease.
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Incidence and short-term outcomes of Kawasaki disease.
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Enfant d'âge préscolaire › Incidence and short-term outcomes of Kawasaki disease.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Incidence and short-term outcomes of Kawasaki disease.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Registre civil › Morbidité › Incidence › Incidence and short-term outcomes of Kawasaki disease.
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Dermatoses vasculaires › Maladie de Kawasaki › Incidence and short-term outcomes of Kawasaki disease.
questionsmedicales.fr › Régions géographiques › Amériques › Amérique du Nord › Canada › Ontario › Incidence and short-term outcomes of Kawasaki disease.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études rétrospectives › Incidence and short-term outcomes of Kawasaki disease.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Incidence and short-term outcomes of Kawasaki disease.
questionsmedicales.fr › Qualité, accès, évaluation des soins de santé › Qualité des soins de santé › Mécanismes d'évaluation des soins de santé › Évaluation des résultats et des processus en soins de santé › Évaluation de résultat (soins) › Résultat thérapeutique › Incidence and short-term outcomes of Kawasaki disease.