Asymmetric optic disc edema in a young patient with POEMS: A rare presentation of a rare disease.
Infiltrative orbitopathy
Optic disc edema
POEMS syndrome
Vascular endothelial growth factor
Journal
American journal of ophthalmology case reports
ISSN: 2451-9936
Titre abrégé: Am J Ophthalmol Case Rep
Pays: United States
ID NLM: 101679941
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
received:
10
06
2020
revised:
11
11
2020
accepted:
21
02
2021
entrez:
31
3
2021
pubmed:
1
4
2021
medline:
1
4
2021
Statut:
epublish
Résumé
To describe a case of asymmetric optic disc edema presenting as the initial ocular feature of POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammopathy, Skin changes) syndrome. A 29-year-old female patient presented with 3 weeks history of blurred vision, proptosis, and peripheral neuropathy as well as hypothyroidism. Fundoscopy revealed optic disc edema associated with visual loss in the left eye. Following a computed tomography (CT) scan and a positron emission tomography/CT (PET/CT) scan which respectively revealed hepatomegaly and multiple osteosclerotic lesions, as well as laboratory findings of monoclonal gammopathy and elevated vascular endothelial growth factor (VEGF) levels, she was diagnosed with POEMS syndrome. After treatment with an autologous stem cell transplant, the optic disc edema and blurred vision resolved. The most reported ocular manifestation of POEMS syndrome, a rare and complex multisystem disorder, is bilateral optic disc edema that typically occurs in older males. Therefore, this report presents an uncommon case of asymmetric optic disc edema in a younger, female patient.
Identifiants
pubmed: 33786404
doi: 10.1016/j.ajoc.2021.101064
pii: S2451-9936(21)00055-4
pmc: PMC7994727
doi:
Types de publication
Case Reports
Langues
eng
Pagination
101064Informations de copyright
© 2021 The Authors.
Déclaration de conflit d'intérêts
Dr. Amer Assal wishes to disclose advisory board participation with Incyte Corporation and Boston Biomedical, as well as research funding received from Incyte Corporation. The following authors have no financial disclosures: HM, JKR, DB, DCP, GM.
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