Flavonoids as potential phytotherapeutics to combat cytokine storm in SARS-CoV-2.
COVID-19
Cytokine storm
Flavonoids
Immunomodulation
Inflammatory cytokines
Phytotherapeutics
Journal
Phytotherapy research : PTR
ISSN: 1099-1573
Titre abrégé: Phytother Res
Pays: England
ID NLM: 8904486
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
revised:
22
02
2021
received:
04
01
2021
accepted:
12
03
2021
pubmed:
1
4
2021
medline:
15
9
2021
entrez:
31
3
2021
Statut:
ppublish
Résumé
Emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, COVID-19, has become the global panic since December 2019, which urges the global healthcare professionals to identify novel therapeutics to counteract this pandemic. So far, there is no approved treatment available to control this public health issue; however, a few antiviral agents and repurposed drugs support the patients under medical supervision by compromising their adverse effects, especially in emergency conditions. Only a few vaccines have been approved to date. In this context, several plant natural products-based research studies are evidenced to play a crucial role in immunomodulation that can prevent the chances of infection as well as combat the cytokine release storm (CRS) generated during COVID-19 infection. In this present review, we have focused on flavonoids, especially epicatechin, epigallocatechin gallate, hesperidin, naringenin, quercetin, rutin, luteolin, baicalin, diosmin, ge nistein, biochanin A, and silymarin, which can counteract the virus-mediated elevated levels of inflammatory cytokines leading to multiple organ failure. In addition, a comprehensive discussion on available in silico, in vitro, and in vivo findings with critical analysis has also been evaluated, which might pave the way for further development of phytotherapeutics to identify the potential lead candidatetoward effective and safe management of the SARS-CoV-2 disease.
Identifiants
pubmed: 33786876
doi: 10.1002/ptr.7092
pmc: PMC8250405
doi:
Substances chimiques
Cytokines
0
Flavonoids
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
4258-4283Informations de copyright
© 2021 John Wiley & Sons Ltd.
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