Discovery of Novel Benzimidazole and Indazole Analogues as Tubulin Polymerization Inhibitors with Potent Anticancer Activities.
Animals
Benzimidazoles
/ chemistry
Binding Sites
Cell Cycle Checkpoints
/ drug effects
Cell Line, Tumor
Cell Proliferation
/ drug effects
Crystallography, X-Ray
Disease Models, Animal
Drug Design
Drug Resistance, Neoplasm
/ drug effects
Drug Screening Assays, Antitumor
Humans
Male
Melanoma
/ drug therapy
Mice
Mice, Inbred BALB C
Molecular Dynamics Simulation
Structure-Activity Relationship
Tubulin
/ chemistry
Tubulin Modulators
/ chemistry
Journal
Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531
Informations de publication
Date de publication:
22 04 2021
22 04 2021
Historique:
pubmed:
1
4
2021
medline:
17
6
2021
entrez:
31
3
2021
Statut:
ppublish
Résumé
Novel indazole and benzimidazole analogues were designed and synthesized as tubulin inhibitors with potent antiproliferative activities. Among them, compound
Identifiants
pubmed: 33788562
doi: 10.1021/acs.jmedchem.0c01837
doi:
Substances chimiques
Benzimidazoles
0
Tubulin
0
Tubulin Modulators
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM