Poverty, sanitation, and Leptospira transmission pathways in residents from four Brazilian slums.
Journal
PLoS neglected tropical diseases
ISSN: 1935-2735
Titre abrégé: PLoS Negl Trop Dis
Pays: United States
ID NLM: 101291488
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
18
08
2020
accepted:
19
02
2021
revised:
12
04
2021
pubmed:
1
4
2021
medline:
6
7
2021
entrez:
31
3
2021
Statut:
epublish
Résumé
Residents of urban slums suffer from a high burden of zoonotic diseases due to individual, socioeconomic, and environmental factors. We conducted a cross-sectional sero-survey in four urban slums in Salvador, Brazil, to characterize how poverty and sanitation contribute to the transmission of rat-borne leptospirosis. Sero-prevalence in the 1,318 participants ranged between 10.0 and 13.3%. We found that contact with environmental sources of contamination, rather than presence of rat reservoirs, is what leads to higher risk for residents living in areas with inadequate sanitation. Further, poorer residents may be exposed away from the household, and ongoing governmental interventions were not associated with lower transmission risk. Residents at higher risk were aware of their vulnerability, and their efforts improved the physical environment near their household, but did not reduce their infection chances. This study highlights the importance of understanding the socioeconomic and environmental determinants of risk, which ought to guide intervention efforts.
Identifiants
pubmed: 33788864
doi: 10.1371/journal.pntd.0009256
pii: PNTD-D-20-01485
pmc: PMC8041187
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0009256Subventions
Organisme : Medical Research Council
ID : MR/P024084/1
Pays : United Kingdom
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : Wellcome Trust
ID : 102330/Z/13/Z
Pays : United Kingdom
Organisme : FIC NIH HHS
ID : R01 TW009504
Pays : United States
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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