Excitatory granule neuron precursors orchestrate laminar localization and differentiation of cerebellar inhibitory interneuron subtypes.

Animals Axons / metabolism Cell Differentiation Cell Movement Cytoplasmic Granules / metabolism GABAergic Neurons / cytology Interneurons / cytology Mice, Transgenic
GABA basket cell cell type cerebellum interneuron stellate cell tangential migration

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
30 03 2021
Historique:
received: 26 03 2020
revised: 19 12 2020
accepted: 03 03 2021
entrez: 31 3 2021
pubmed: 1 4 2021
medline: 27 1 2022
Statut: ppublish

Résumé

GABAergic interneurons migrate long distances through stereotyped migration programs toward specific laminar positions. During their migration, GABAergic interneurons are morphologically alike but then differentiate into a rich array of interneuron subtypes critical for brain function. How interneuron subtypes acquire their final phenotypic traits remains largely unknown. Here, we show that cerebellar molecular layer GABAergic interneurons, derived from the same progenitor pool, use separate migration paths to reach their laminar position and differentiate into distinct basket cell (BC) and stellate cell (SC) GABAergic interneuron subtypes. Using two-photon live imaging, we find that SC final laminar position requires an extra step of tangential migration supported by a subpopulation of glutamatergic granule cells (GCs). Conditional depletion of GCs affects SC differentiation but does not affect BCs. Our results reveal how timely feedforward control of inhibitory interneuron migration path regulates their terminal differentiation and, thus, establishment of the local inhibitory circuit assembly.

Identifiants

DOI: 10.1016/j.celrep.2021.108904 PMID: 33789110
pubmed: 33789110
pii: S2211-1247(21)00218-7
doi: 10.1016/j.celrep.2021.108904
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

108904

Subventions

Organisme : Medical Research Council
ID : MR/N00275X/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S025618/1
Pays : United Kingdom
Organisme : Diabetes UK
ID : 17/0005681
Pays : United Kingdom

Informations de copyright

Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

Auteurs

Christelle Cadilhac (C)

IGF, University Montpellier, CNRS, INSERM, Montpellier, France.

Isabelle Bachy (I)

IGF, University Montpellier, CNRS, INSERM, Montpellier, France.

Antoine Forget (A)

Institut Curie, Université PSL, CNRS UMR3347, INSERM U1021, Signaling Radiobiology and Cancer, 91400 Orsay, France; Université Paris-Saclay, CNRS UMR3347, INSERM U1021, Signaling Radiobiology and Cancer, 91400 Orsay, France.

David J Hodson (DJ)

Institute of Metabolism and Systems Research and Centre of Membrane Proteins and Receptors, University of Birmingham, Edgbaston B15 2TT, UK.

Céline Jahannault-Talignani (C)

IGF, University Montpellier, CNRS, INSERM, Montpellier, France.

Andrew J Furley (AJ)

Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK.

Olivier Ayrault (O)

Institut Curie, Université PSL, CNRS UMR3347, INSERM U1021, Signaling Radiobiology and Cancer, 91400 Orsay, France; Université Paris-Saclay, CNRS UMR3347, INSERM U1021, Signaling Radiobiology and Cancer, 91400 Orsay, France.

Patrice Mollard (P)

IGF, University Montpellier, CNRS, INSERM, Montpellier, France.

Constantino Sotelo (C)

Institut de la Vision INSERM, UMRS_U968, Paris, France.

Fabrice Ango (F)

IGF, University Montpellier, CNRS, INSERM, Montpellier, France; INM, University Montpellier, INSERM, CNRS, Montpellier, France. Electronic address: fabrice.ango@inserm.fr.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Excitatory granule neuron precursors...
questionsmedicales.fr › Cellules › Neurones › Neurofibres › Axones › Excitatory granule neuron precursors...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Excitatory granule neuron precursors...
questionsmedicales.fr › Phénomènes physiologiques › Mouvement cellulaire › Excitatory granule neuron precursors...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Vésicules cytoplasmiques › Granulations cytoplasmiques › Excitatory granule neuron precursors...
questionsmedicales.fr › Cellules › Neurones › Neurones GABAergiques › Excitatory granule neuron precursors...
questionsmedicales.fr › Cellules › Neurones › Interneurones › Excitatory granule neuron precursors...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Excitatory granule neuron precursors...