The Ubiquitinated Axon: Local Control of Axon Development and Function by Ubiquitin.
axons
neuronal disorders
presynaptic terminal
ubiquitin
ubiquitin-proteasome system
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
31 03 2021
31 03 2021
Historique:
received:
31
08
2020
revised:
15
01
2021
accepted:
22
01
2021
entrez:
1
4
2021
pubmed:
2
4
2021
medline:
18
8
2021
Statut:
ppublish
Résumé
Ubiquitin tagging sets protein fate. With a wide range of possible patterns and reversibility, ubiquitination can assume many shapes to meet specific demands of a particular cell across time and space. In neurons, unique cells with functionally distinct axons and dendrites harboring dynamic synapses, the ubiquitin code is exploited at the height of its power. Indeed, wide expression of ubiquitination and proteasome machinery at synapses, a diverse brain ubiquitome, and the existence of ubiquitin-related neurodevelopmental diseases support a fundamental role of ubiquitin signaling in the developing and mature brain. While special attention has been given to dendritic ubiquitin-dependent control, how axonal biology is governed by this small but versatile molecule has been considerably less discussed. Herein, we set out to explore the ubiquitin-mediated spatiotemporal control of an axon's lifetime: from its differentiation and growth through presynaptic formation, function, and pruning.
Identifiants
pubmed: 33789876
pii: 41/13/2796
doi: 10.1523/JNEUROSCI.2251-20.2021
pmc: PMC8018891
doi:
Substances chimiques
Ubiquitin
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2796-2813Informations de copyright
Copyright © 2021 the authors.
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