Cognitive Impairment and Associated Factors Among Adult Hypothyroid Patients in Referral Hospitals, Amhara Region, Ethiopia: Multicenter Cross-Sectional Study.
Ethiopia
SMMSE
cognitive impairment
hypothyroidism
Journal
Neuropsychiatric disease and treatment
ISSN: 1176-6328
Titre abrégé: Neuropsychiatr Dis Treat
Pays: New Zealand
ID NLM: 101240304
Informations de publication
Date de publication:
2021
2021
Historique:
received:
30
12
2020
accepted:
11
03
2021
entrez:
1
4
2021
pubmed:
2
4
2021
medline:
2
4
2021
Statut:
epublish
Résumé
Cognitive impairment is a common complication of hypothyroidism that affects the patient's quality of life in different aspects. In Ethiopia, though the prevalence of hypothyroidism is high the magnitude of cognitive impairment among these patients is not known. Therefore, the current study is aimed at determining the prevalence of cognitive impairment and associated factors among adult hypothyroid patients. An institution-based cross-sectional study was employed from February 24 to May 22, 2020, to assess the prevalence of cognitive impairment and associated factors among adult hypothyroid patients. Data was collected by a pretested interviewer-administered structured questionnaire and standardized Mini-mental state examination (SMMSE) tool. A cluster sampling technique was used. Data was entered into Epidata version 4.6 and exported into a statistical package for social science (SPSS) version 25 for further analysis. Both bivariable and multivariable logistic regression analyses were done. A 95% confidence interval and P-value <0.05 were used to declare statistical significance. A total of 216 adult hypothyroid patients were included with a response rate of 98.6%. The mean age was 42.5 (± 11) years. The prevalence of cognitive impairment was 27.3% (95% CI (21.7, 33.8)) and it was significantly associated with increased age (AOR = 1.23, 95% CI (1.11, 1.34)), increased duration of illness (AOR = 1.48, 95% CI (1.14, 1.90)) and high thyroid-stimulating hormone (TSH) level (AOR = 1.3, 95% CI (1.1, 1.6)). The prevalence of cognitive impairment among hypothyroid patients was high. Increased age, increased duration of illness and high TSH levels were significantly associated with cognitive impairment. Hence, early screening of cognitive impairment among hypothyroid patients with increased age, increased duration of illness and high TSH level should be given due emphasis to increase patients quality of life.
Sections du résumé
BACKGROUND
BACKGROUND
Cognitive impairment is a common complication of hypothyroidism that affects the patient's quality of life in different aspects. In Ethiopia, though the prevalence of hypothyroidism is high the magnitude of cognitive impairment among these patients is not known. Therefore, the current study is aimed at determining the prevalence of cognitive impairment and associated factors among adult hypothyroid patients.
METHODS
METHODS
An institution-based cross-sectional study was employed from February 24 to May 22, 2020, to assess the prevalence of cognitive impairment and associated factors among adult hypothyroid patients. Data was collected by a pretested interviewer-administered structured questionnaire and standardized Mini-mental state examination (SMMSE) tool. A cluster sampling technique was used. Data was entered into Epidata version 4.6 and exported into a statistical package for social science (SPSS) version 25 for further analysis. Both bivariable and multivariable logistic regression analyses were done. A 95% confidence interval and P-value <0.05 were used to declare statistical significance.
RESULTS
RESULTS
A total of 216 adult hypothyroid patients were included with a response rate of 98.6%. The mean age was 42.5 (± 11) years. The prevalence of cognitive impairment was 27.3% (95% CI (21.7, 33.8)) and it was significantly associated with increased age (AOR = 1.23, 95% CI (1.11, 1.34)), increased duration of illness (AOR = 1.48, 95% CI (1.14, 1.90)) and high thyroid-stimulating hormone (TSH) level (AOR = 1.3, 95% CI (1.1, 1.6)).
CONCLUSION
CONCLUSIONS
The prevalence of cognitive impairment among hypothyroid patients was high. Increased age, increased duration of illness and high TSH levels were significantly associated with cognitive impairment. Hence, early screening of cognitive impairment among hypothyroid patients with increased age, increased duration of illness and high TSH level should be given due emphasis to increase patients quality of life.
Identifiants
pubmed: 33790562
doi: 10.2147/NDT.S299840
pii: 299840
pmc: PMC8007569
doi:
Types de publication
Journal Article
Langues
eng
Pagination
935-943Informations de copyright
© 2021 Mulat et al.
Déclaration de conflit d'intérêts
The authors report no conflicts of interest for this work.
Références
Psychol Med. 2014 Jul;44(10):2029-40
pubmed: 24168753
Br J Psychiatry. 2001 Mar;178:200-6
pubmed: 11230029
Lancet. 2017 Sep 23;390(10101):1550-1562
pubmed: 28336049
J Clin Endocrinol Metab. 2009 Aug;94(8):2922-9
pubmed: 19435829
Vitam Horm. 2005;71:95-122
pubmed: 16112266
WHO South East Asia J Public Health. 2014 Apr-Jun;3(2):135-143
pubmed: 28607299
Trends Cogn Sci. 2012 Feb;16(2):106-13
pubmed: 22245618
Biomed Res Int. 2017;2017:2726369
pubmed: 28503567
Indian J Endocrinol Metab. 2014 Nov;18(6):811-4
pubmed: 25364675
Curr Opin Endocrinol Diabetes Obes. 2008 Oct;15(5):429-33
pubmed: 18769215
Semin Hear. 2015 Aug;36(3):111-21
pubmed: 27516712
Curr Pharm Des. 2012;18(32):5165-87
pubmed: 22716157
Can Fam Physician. 2001 Oct;47:2018-23
pubmed: 11723596
Gen Hosp Psychiatry. 2014 Nov-Dec;36(6):627-33
pubmed: 25267696
Endocr Pract. 2002 Nov-Dec;8(6):457-69
pubmed: 15260011
Curr Gerontol Geriatr Res. 2008;:474868
pubmed: 19415145
Am J Occup Ther. 2007 Mar-Apr;61(2):135-40
pubmed: 17436834
Psychoneuroendocrinology. 2008 Aug;33(7):1013-22
pubmed: 18640783
Ethiop Med J. 2012 Oct;50(4):287-95
pubmed: 23930473
JAMA Neurol. 2014 Feb;71(2):201-7
pubmed: 24378475
J Am Geriatr Soc. 1992 Apr;40(4):325-35
pubmed: 1556359
Thyroid. 2015 Jan;25(1):28-36
pubmed: 25381990
Am J Occup Ther. 2002 Mar-Apr;56(2):171-9
pubmed: 11905301
Front Hum Neurosci. 2009 Sep 25;3:26
pubmed: 19826496
Thyroid. 2001 Dec;11(12):1177-85
pubmed: 12186506
Prog Neurobiol. 1992 Sep;39(3):281-94
pubmed: 1502339