Recognizing Prognostic and Predictive Biomarkers in the Treatment of Non-Small Cell Lung Cancer (NSCLC) with Immune Checkpoint Inhibitors (ICIs).
NSCLC
biomarkers
immunotherapy
Journal
Lung Cancer (Auckland, N.Z.)
ISSN: 1179-2728
Titre abrégé: Lung Cancer (Auckl)
Pays: New Zealand
ID NLM: 101632521
Informations de publication
Date de publication:
2021
2021
Historique:
received:
10
12
2020
accepted:
20
02
2021
entrez:
1
4
2021
pubmed:
2
4
2021
medline:
2
4
2021
Statut:
epublish
Résumé
Immunotherapy plays a central role in the treatment of NSCLC and biomarkers predicting response to ICIs are valuable therapeutic tools. Programmed death-ligand 1 (PD-L1) immunohistochemistry (IHC) is integral in therapy selection as its positive predictive nature to ICIs in the metastatic setting is well documented. Tumor mutational burden (TMB) has undergone much study and, while results are somewhat mixed, there is evidence for its positive predictive value with ICI use. Additional markers such as tumor-infiltrating lymphocytes (TILs), gene expression profiling (GEP), mismatch repair (MMR) and microsatellite instability (MSI), somatic mutations, neutrophil to leukocyte ratio (NLR), smoking history, medication history, and immune-related adverse event (irAE) development can further guide clinicians.
Identifiants
pubmed: 33790679
doi: 10.2147/LCTT.S235102
pii: 235102
pmc: PMC8006757
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
21-34Informations de copyright
© 2021 Giustini and Bazhenova.
Déclaration de conflit d'intérêts
Dr Lyudmila Bazhenova reports personal fees from Boehringer-Ingelheim. The authors report no other conflicts of interest in this work.
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