A Plausible Role for Collectins in Skin Immune Homeostasis.
collectins
immune homeostasis
immunity
immunotherapy
skin
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
14
08
2020
accepted:
25
02
2021
entrez:
1
4
2021
pubmed:
2
4
2021
medline:
29
6
2021
Statut:
epublish
Résumé
The skin is a complex organ that faces the external environment and participates in the innate immune system. Skin immune homeostasis is necessary to defend against external microorganisms and to recover from stress to the skin. This homeostasis depends on interactions among a variety of cells, cytokines, and the complement system. Collectins belong to the lectin pathway of the complement system, and have various roles in innate immune responses. Mannose-binding lectin (MBL), collectin kidney 1, and liver (CL-K1, CL-L1) activate the lectin pathway, while all have multiple functions, including recognition of pathogens, opsonization of phagocytosis, and modulation of cytokine-mediated inflammatory responses. Certain collectins are localized in the skin, and their expressions change during skin diseases. In this review, we summarize important advances in our understanding of how MBL, surfactant proteins A and D, CL-L1, and CL-K1 function in skin immune homeostasis. Based on the potential roles of collectins in skin diseases, we suggest therapeutic strategies for skin diseases through the targeting of collectins and relevant regulators.
Identifiants
pubmed: 33790889
doi: 10.3389/fimmu.2021.594858
pmc: PMC8006919
doi:
Substances chimiques
Biomarkers
0
Collectins
0
Complement System Proteins
9007-36-7
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
594858Informations de copyright
Copyright © 2021 Wang, Li, Xiao and Xia.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Vaccine. 2003 Jun 1;21 Suppl 2:S12-23
pubmed: 12763678
Scand J Immunol. 2016 Jul;84(1):12-9
pubmed: 27104295
Am J Clin Dermatol. 2012 Oct 1;13(5):341-8
pubmed: 22621659
Immunology. 2007 Nov;122(3):335-42
pubmed: 17521368
PLoS Negl Trop Dis. 2018 Dec 10;12(12):e0006945
pubmed: 30532182
Cell Physiol Biochem. 2010;25(1):13-26
pubmed: 20054141
Immunobiology. 2013 Apr;218(4):652-63
pubmed: 22906751
J Exp Med. 1990 Oct 1;172(4):1071-82
pubmed: 2212943
Mol Immunol. 2005 Mar;42(5):581-7
pubmed: 15607817
Arthritis Res Ther. 2012 Oct 15;14(5):R218
pubmed: 23068019
J Innate Immun. 2017;9(2):217-228
pubmed: 28068663
J Immunol Methods. 2012 Jan 31;375(1-2):182-8
pubmed: 22301270
Immunobiology. 2002 Sep;205(4-5):498-517
pubmed: 12396011
Eur Rev Med Pharmacol Sci. 2019 Oct;23(20):9085-9092
pubmed: 31696499
J Immunol. 2010 Oct 1;185(7):3884-94
pubmed: 20810986
J Immunol. 2009 Sep 1;183(5):3496-504
pubmed: 19657091
Clin Exp Immunol. 1992 Oct;90(1):31-5
pubmed: 1395098
Eur J Biochem. 2004 Apr;271(7):1229-49
pubmed: 15030473
Microb Pathog. 2016 Oct;99:282-286
pubmed: 27585546
J Leukoc Biol. 2020 Aug;108(2):485-491
pubmed: 32170886
Infect Disord Drug Targets. 2008 Sep;8(3):144-55
pubmed: 18782031
Front Immunol. 2018 Apr 16;9:639
pubmed: 29713318
J Rheumatol. 2018 Aug;45(8):1136-1144
pubmed: 29907670
Mol Immunol. 2007 Apr;44(11):2943-9
pubmed: 17320177
Nat Rev Immunol. 2014 May;14(5):286
pubmed: 24762825
Microbiol Immunol. 2006;50(12):1001-13
pubmed: 17179669
J Invest Dermatol. 2007 Feb;127(2):381-6
pubmed: 17008883
J Invest Dermatol. 2002 Dec;119(6):1394-9
pubmed: 12485445
J Immunol. 2010 Oct 1;185(7):4169-78
pubmed: 20817870
Circulation. 2012 Oct 30;126(18):2227-35
pubmed: 23032324
Int Immunol. 2007 Feb;19(2):141-9
pubmed: 17182967
Hum Immunol. 2014 Jul;75(7):629-32
pubmed: 24798938
J Allergy Clin Immunol. 2006 Jul;118(1):202-8
pubmed: 16815156
J Invest Dermatol. 2007 Jun;127(6):1524-31
pubmed: 17363917
BMC Infect Dis. 2015 Mar 25;15:151
pubmed: 25887173
Innate Immun. 2010 Jun;16(3):191-200
pubmed: 20529971
Front Immunol. 2018 Jun 27;9:1406
pubmed: 29997613
Arch Dermatol Res. 2008 Aug;300(7):353-6
pubmed: 18386026
Pflugers Arch. 2017 Apr;469(3-4):455-463
pubmed: 28233123
Development. 2010 Aug;137(16):2605-21
pubmed: 20663816
Int J Mol Sci. 2019 Apr 12;20(8):
pubmed: 31013709
J Innate Immun. 2017;9(1):3-11
pubmed: 27794581
J Immunol. 2006 Apr 1;176(7):4431-9
pubmed: 16547281
Semin Immunopathol. 2018 Jan;40(1):75-85
pubmed: 28894916
J Biol Chem. 2013 Aug 9;288(32):23407-20
pubmed: 23814060
Exp Dermatol. 2006 Mar;15(3):168-74
pubmed: 16480424
Kidney Int. 2016 Oct;90(4):774-82
pubmed: 27378476
Knee Surg Sports Traumatol Arthrosc. 2015 Sep;23(9):2682-9
pubmed: 24809505
Clin Dermatol. 2001 Sep-Oct;19(5):563-72
pubmed: 11604303
Trends Immunol. 2006 Feb;27(2):102-8
pubmed: 16406700
J Innate Immun. 2017;9(6):529-545
pubmed: 28772263
Mol Immunol. 2014 Oct;61(2):174-84
pubmed: 25044097
Pigment Cell Melanoma Res. 2014 Jan;27(1):103-12
pubmed: 24011128
Am J Respir Crit Care Med. 2008 Jul 15;178(2):158-67
pubmed: 18420961
Genet Mol Biol. 2019 Jan-Mar;42(1):9-14
pubmed: 30794720
J Cereb Blood Flow Metab. 2017 Mar;37(3):938-950
pubmed: 27165013
Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):15061-6
pubmed: 23980152
Cell. 2003 Oct 3;115(1):13-23
pubmed: 14531999
Innate Immun. 2010 Jun;16(3):175-82
pubmed: 20423921
Science. 2014 Oct 3;346(6205):101-5
pubmed: 25278612
Am J Pathol. 2015 Feb;185(2):347-55
pubmed: 25482922
Pediatr Res. 2016 Aug;80(2):237-43
pubmed: 27057739
J Immunol. 2006 Feb 1;176(3):1769-75
pubmed: 16424207
Am Heart J. 2012 Jul;164(1):43-51
pubmed: 22795281
Mol Immunol. 2007 Sep;44(16):3875-88
pubmed: 17768106
Cell Mol Immunol. 2013 Mar;10(2):113-21
pubmed: 23396472
Nat Genet. 2011 Mar;43(3):197-203
pubmed: 21258343
J Clin Invest. 2003 May;111(10):1589-602
pubmed: 12750409
Hum Immunol. 2013 Jan;74(1):114-9
pubmed: 23000377
Arch Dermatol Res. 2011 Sep;303(7):521-5
pubmed: 21327568
J Oral Sci. 2020;62(3):293-297
pubmed: 32581176
Immunobiology. 2007;212(3):151-7
pubmed: 17412282
J Invest Dermatol. 2005 Jul;125(1):166-73
pubmed: 15982317
Blood. 2000 Nov 1;96(9):3086-93
pubmed: 11049988
PLoS One. 2015 Feb 24;10(2):e0114883
pubmed: 25710878
Sci Rep. 2016 Nov 23;6:35728
pubmed: 27876780
Am J Trop Med Hyg. 2019 Dec;101(6):1322-1324
pubmed: 31549610
J Biol Chem. 1999 May 7;274(19):13681-9
pubmed: 10224141
J Immunol. 2019 Dec 15;203(12):3091
pubmed: 31818918
J Immunol. 2013 Dec 15;191(12):6117-27
pubmed: 24174618
J Leukoc Biol. 2006 Jul;80(1):107-16
pubmed: 16617157
Neuromolecular Med. 2014 Sep;16(3):551-64
pubmed: 24801942
Mol Immunol. 2013 Dec;56(4):757-67
pubmed: 23954398
Front Immunol. 2018 Aug 08;9:1851
pubmed: 30135690
PLoS Genet. 2017 Mar 16;13(3):e1006679
pubmed: 28301481
Clin Exp Immunol. 2015 Nov;182(2):132-8
pubmed: 26154564
Lung. 2013 Jun;191(3):295-303
pubmed: 23435873
Br J Dermatol. 2002 Jan;146(1):80-7
pubmed: 11841370
J Clin Immunol. 2019 Oct;39(7):668-677
pubmed: 31377972
Biochim Biophys Acta. 2009 Dec;1790(12):1705-10
pubmed: 19840833
Respir Res. 2016 Jun 01;17(1):66
pubmed: 27250970
J Immunol. 2012 Jun 15;188(12):6027-35
pubmed: 22561151
J Rheumatol. 2009 Nov;36(11):2449-53
pubmed: 19833760
J Exp Med. 2009 Apr 13;206(4):743-50
pubmed: 19307328
Immunobiology. 2012 Sep;217(9):851-63
pubmed: 22475410
J Allergy Clin Immunol. 2007 May;119(5):1210-7
pubmed: 17472813
J Mol Histol. 2012 Jun;43(3):361-9
pubmed: 22389028
J Immunol. 2000 Jun 1;164(11):5866-70
pubmed: 10820266
Front Immunol. 2017 Nov 29;8:1676
pubmed: 29238347
Front Immunol. 2018 Sep 04;9:1998
pubmed: 30233589
Mol Immunol. 2009 Feb;46(4):688-94
pubmed: 18950866
Front Immunol. 2018 Jul 31;9:1757
pubmed: 30108587
Biosci Biotechnol Biochem. 2002 Oct;66(10):2134-45
pubmed: 12450124
Clin Exp Immunol. 2018 Oct;194(1):79-92
pubmed: 30030847
Int Immunopharmacol. 2018 Oct;63:161-169
pubmed: 30096599
Clin Mol Allergy. 2010 Mar 25;8:6
pubmed: 20338057
Exp Dermatol. 2019 Sep;28(9):1017-1024
pubmed: 31260126
J Immunol. 2010 Nov 15;185(10):6096-104
pubmed: 20956340