Harnessing Mesenchymal Stromal Cells for the Engineering of Human Hematopoietic Niches.
3D culture
bone marrow niche
hematopoiesis
mesenchymal stroma cell
organoids model
thymus epithelial cell
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
19
11
2020
accepted:
10
02
2021
entrez:
1
4
2021
pubmed:
2
4
2021
medline:
16
9
2021
Statut:
epublish
Résumé
Tissue engineering opens multiple opportunities in regenerative medicine, drug testing, and modeling of the hematopoiesis in health and disease. Recapitulating the organization of physiological microenvironments supporting leukocyte development is essential to model faithfully the development of immune cells. Hematopoietic organs are shaped by spatially organized niches defined by multiple cellular contributions. A shared feature of immune niches is the presence of mesenchymal stromal cells endowed with unique roles in organizing niche development, maintenance, and function. Here, we review challenges and opportunities in harnessing stromal cells for the engineering of artificial immune niches and hematopoietic organoids recapitulating leukocyte ontogeny both
Identifiants
pubmed: 33790904
doi: 10.3389/fimmu.2021.631279
pmc: PMC8006008
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
631279Subventions
Organisme : Biotechnology and Biological Sciences Research Council
Pays : United Kingdom
Informations de copyright
Copyright © 2021 Pievani, Savoldelli, Poelchen, Mattioli, Anselmi, Girardot, Utikal, Bourdely, Serafini and Guermonprez.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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