Pro-organic radical contrast agents ("pro-ORCAs") for real-time MRI of pro-drug activation in biological systems.
Journal
Polymer chemistry
ISSN: 1759-9954
Titre abrégé: Polym Chem
Pays: England
ID NLM: 101562526
Informations de publication
Date de publication:
07 Aug 2020
07 Aug 2020
Historique:
entrez:
1
4
2021
pubmed:
2
4
2021
medline:
2
4
2021
Statut:
ppublish
Résumé
Nitroxide-based organic-radical contrast agents (ORCAs) are promising as safe, next-generation magnetic resonance imaging (MRI) tools. Nevertheless, stimuli-responsive ORCAs that enable MRI monitoring of prodrug activation have not been reported; such systems could open new avenues for prodrug validation and image-guided drug delivery. Here, we introduce a novel "pro-ORCA" concept that addresses this challenge. By covalent conjugation of nitroxides and drug molecules (doxorubicin, DOX) to the same brush-arm star polymer (BASP) through chemically identical cleavable linkers, we demonstrate that pro-ORCA and prodrug activation,
Identifiants
pubmed: 33790990
doi: 10.1039/d0py00558d
pmc: PMC8009311
mid: NIHMS1610607
doi:
Types de publication
Journal Article
Langues
eng
Pagination
4768-4779Subventions
Organisme : NCI NIH HHS
ID : R01 CA220468
Pays : United States
Déclaration de conflit d'intérêts
Conflicts of interest There are no conflicts to declare.
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