Click and Release Chemistry for Activity-Based Purification of β-Lactam Targets.
Activity-based probe
Antibiotic
Click and release
Iminosydnone
Peptidoglycan
Journal
Chemistry (Weinheim an der Bergstrasse, Germany)
ISSN: 1521-3765
Titre abrégé: Chemistry
Pays: Germany
ID NLM: 9513783
Informations de publication
Date de publication:
17 May 2021
17 May 2021
Historique:
received:
21
02
2021
pubmed:
2
4
2021
medline:
22
5
2021
entrez:
1
4
2021
Statut:
ppublish
Résumé
β-Lactams, the cornerstone of antibiotherapy, inhibit multiple and partially redundant targets referred to as transpeptidases or penicillin-binding proteins. These enzymes catalyze the essential cross-linking step of the polymerization of cell wall peptidoglycan. The understanding of the mechanisms of action of β-lactams and of resistance to these drugs requires the development of reliable methods to characterize their targets. Here, we describe an activity-based purification method of β-lactam targets based on click and release chemistry. We synthesized alkyne-carbapenems with suitable properties with respect to the kinetics of acylation of a model target, the Ldt
Identifiants
pubmed: 33792096
doi: 10.1002/chem.202100653
doi:
Substances chimiques
Anti-Bacterial Agents
0
Carbapenems
0
Penicillin-Binding Proteins
0
Peptidoglycan
0
beta-Lactams
0
Peptidyl Transferases
EC 2.3.2.12
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
7687-7695Subventions
Organisme : Ecole doctorale MTCI
Informations de copyright
© 2021 Wiley-VCH GmbH.
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