Glucagon's Metabolic Action in Health and Disease.
Journal
Comprehensive Physiology
ISSN: 2040-4603
Titre abrégé: Compr Physiol
Pays: United States
ID NLM: 101574442
Informations de publication
Date de publication:
01 04 2021
01 04 2021
Historique:
entrez:
1
4
2021
pubmed:
2
4
2021
medline:
26
10
2021
Statut:
epublish
Résumé
Discovered almost simultaneously with insulin, glucagon is a pleiotropic hormone with metabolic action that goes far beyond its classical role to increase blood glucose. Albeit best known for its ability to directly act on the liver to increase de novo glucose production and to inhibit glycogen breakdown, glucagon lowers body weight by decreasing food intake and by increasing metabolic rate. Glucagon further promotes lipolysis and lipid oxidation and has positive chronotropic and inotropic effects in the heart. Interestingly, recent decades have witnessed a remarkable renaissance of glucagon's biology with the acknowledgment that glucagon has pharmacological value beyond its classical use as rescue medication to treat severe hypoglycemia. In this article, we summarize the multifaceted nature of glucagon with a special focus on its hepatic action and discuss the pharmacological potential of either agonizing or antagonizing the glucagon receptor for health and disease. © 2021 American Physiological Society. Compr Physiol 11:1759-1783, 2021.
Identifiants
pubmed: 33792899
doi: 10.1002/cphy.c200013
pmc: PMC8513137
mid: NIHMS1746156
doi:
Substances chimiques
Blood Glucose
0
Insulin
0
Glucagon
9007-92-5
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1759-1783Subventions
Organisme : NIDDK NIH HHS
ID : P30 DK056336
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK079626
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK112934
Pays : United States
Informations de copyright
Copyright © 2021 American Physiological Society. All rights reserved.
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