Strenuous 12-h run elevates circulating biomarkers of oxidative stress, inflammation and intestinal permeability in middle-aged amateur runners: A preliminary study.
Antioxidants
/ metabolism
Athletes
Biomarkers
/ blood
C-Reactive Protein
/ metabolism
Exercise
/ physiology
Gastrointestinal Tract
/ injuries
Haptoglobins
Humans
Inflammation
/ blood
Male
Middle Aged
Muscle, Skeletal
/ injuries
Oxidants
/ blood
Oxidative Stress
/ genetics
Permeability
Protein Precursors
/ blood
Stress, Physiological
/ physiology
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2021
2021
Historique:
received:
14
07
2020
accepted:
13
03
2021
entrez:
1
4
2021
pubmed:
2
4
2021
medline:
22
9
2021
Statut:
epublish
Résumé
Given the solid evidence that prolonged strenuous exercise is a cause of metabolic stress, this study sought to determine whether a 12-h run would affect total oxidant status (TOS), total oxidant capacity (TOC), total antioxidant status (TAS), high-sensitivity C-reactive protein (hs-CRP) and the biomarkers of intestinal permeability (protein fatty acid-binding proteins (I-FABP) and zonulin) in middle-aged male subjects. Ten amateur long-distance runners (aged 52.0 ± 6.2 years, body height 176.9 ± 4.9 cm, body mass 73.9 ± 6.0 kg) were enrolled in the study. The venous blood samples were collected 1 hour before and right after the run and were analyzed for the levels of TAS, TOS/TOC, hs-CRP, I-FABP and zonulin. The post-run concentrations of TOS/TOC were significantly elevated (p < 0.001), but TAS changes were not significant. Pearson's correlation coefficients calculated for the post run values of TAS and TOS/TOC were statistically significant and negative (r = -0.750, p < 0.05). Significant increases in the concentrations of hs-CRP (p < 0.001), I-FABP (p < 0.05) and zonulin (p < 0.01) were noted. The results indicate that a strenuous 12-h run disturbs the prooxidant-antioxidant balance in middle-aged men, as well as promoting inflammation and impairing intestinal permeability.
Identifiants
pubmed: 33793597
doi: 10.1371/journal.pone.0249183
pii: PONE-D-20-21755
pmc: PMC8016300
doi:
Substances chimiques
Antioxidants
0
Biomarkers
0
Haptoglobins
0
Oxidants
0
Protein Precursors
0
zonulin
0
C-Reactive Protein
9007-41-4
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0249183Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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