Relative faecal abundance of extended-spectrum β-lactamase-producing Enterobacterales and its impact on infections among intensive care unit patients: a pilot study.
Antibiotic stewardship
Antimicrobial resistance
Enterobacterales
Extended-spectrum β-lactamase (ESBL)
Relative faecal abundance
Journal
The Journal of hospital infection
ISSN: 1532-2939
Titre abrégé: J Hosp Infect
Pays: England
ID NLM: 8007166
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
received:
15
12
2020
revised:
05
03
2021
accepted:
05
03
2021
pubmed:
2
4
2021
medline:
19
8
2021
entrez:
1
4
2021
Statut:
ppublish
Résumé
This pilot prospective study assessed the association between the faecal relative abundance of extended-spectrum β-lactamase-producing Enterobacterales (ESBL-PE) and the occurrence of ESBL-PE related infections. Twenty-four patients were included. The median ESBL relative abundance was 32.4%. The mean ESBL-PE relative abundance (ESBL-PE-RA) was more than five-fold higher in patients exposed during the last three months to antibiotics (P = 0.002). Furthermore, the mean ESBL relative abundance was more than two-fold higher in patients colonized with non-E. coli strains (P = 0.044). The mean ESBL-PE-RA was more than 10-fold higher for the concordant patients than for the discordant patients (59.1% vs 4.9%; P < 0.001).
Identifiants
pubmed: 33794294
pii: S0195-6701(21)00143-2
doi: 10.1016/j.jhin.2021.03.022
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
beta-Lactamases
EC 3.5.2.6
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
92-95Informations de copyright
Copyright © 2021 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.