Bolaamphiphile-based supramolecular gels with drugs eliciting membrane effects.
Bolaamphiphiles
Fluorocarbon
Hydrogels
Membrane
Supramolecular
Journal
Journal of colloid and interface science
ISSN: 1095-7103
Titre abrégé: J Colloid Interface Sci
Pays: United States
ID NLM: 0043125
Informations de publication
Date de publication:
15 Jul 2021
15 Jul 2021
Historique:
received:
07
01
2021
revised:
02
03
2021
accepted:
06
03
2021
pubmed:
2
4
2021
medline:
22
6
2021
entrez:
1
4
2021
Statut:
ppublish
Résumé
Supramolecular chemistry has garnered important interest in recent years toward improving therapeutic efficacy via drug delivery approaches. Although self-assemblies have been deeply investigated, the design of novel drugs leveraging supramolecular chemistry is less known. In this contribution, we show that a Low Molecular Weight Gel (LMWG) can elicit cancer cell apoptosis. This biological effect results from the unique supramolecular properties of a bolaamphiphile-based gelator, which allow for strong interaction with the lipid membrane. This novel supramolecular-drug paradigm opens up new possibilities for therapeutic applications targeting membrane lipids.
Identifiants
pubmed: 33794407
pii: S0021-9797(21)00313-1
doi: 10.1016/j.jcis.2021.03.026
pii:
doi:
Substances chimiques
Furans
0
Gels
0
Pyridones
0
bolaamphiphile
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
857-863Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.